Tuberc Respir Dis.  2017 Jan;80(1):45-51. 10.4046/trd.2017.80.1.45.

Incidence of Fever Following Endobronchial Ultrasound–Guided Transbronchial Needle Aspiration

• Kim SY
• Lee JW
• Park YS
• Lee CH
• Lee SM
• Yim JJ
• Kim YW
• Han SK
• Yoo CG

• KMID: 2396340
• DOI: http://doi.org/10.4046/trd.2017.80.1.45

Abstract

BACKGROUND
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic method for mediastinal and hilar lymphadenopathy. This study aimed to investigate the incidence of fever following EBUS-TBNA.
METHODS
A total of 684 patients who underwent EBUS-TBNA from May 2010 to July 2012 at Seoul National University Hospital were retrospectively reviewed. The patients were evaluated for fever by a physician every 6-8 hours during the first 24 hours following EBUS-TBNA. Fever was defined as an increase in axillary body temperature over 37.8℃.
RESULTS
Fever after EBUS-TBNA developed in 110 of 552 patients (20%). The median onset time and duration of fever was 7 hours (range, 0.5-32 hours) after EBUS-TBNA and 7 hours (range, 1-52 hours), respectively, and the median peak body temperature was 38.3℃ (range, 37.8-39.9℃). In most patients, fever subsided within 24 hours; however, six cases (1.1%) developed fever lasting longer than 24 hours. Infectious complications developed in three cases (0.54%) (pneumonia, 2; mediastinal abscess, 1), and all three patients had diabetes mellitus. The number or location of sampled lymph nodes and necrosis of lymph node were not associated with fever after EBUS-TBNA. Multiple logistic regression analysis did not reveal any risk factors for developing fever after EBUS-TBNA.
CONCLUSION
Fever is relatively common after EBUS-TBNA, but is transient in most patients. However, clinicians should be aware of the possibility of infectious complications among patients with diabetes mellitus.

Keyword

Endoscopic Ultrasound-Guided Fine Needle Aspiration; Fever; Infection

MeSH Terms

Abscess
Body Temperature
Diabetes Mellitus
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Fever*
Humans
Incidence*
Logistic Models
Lymph Nodes
Lymphatic Diseases
Methods
Necrosis
Needles*
Retrospective Studies
Risk Factors
Seoul

Figure

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  Figure 1 Changes in peripheral blood white blood cell (WBC) and neutrophil counts before endobronchial ultrasound (EBUS)–guided transbronchial needle aspiration and at the time of fever in the fever group (n=57). *p=0.030. †p<0.001.

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