Ann Dermatol.  2017 Dec;29(6):776-778. 10.5021/ad.2017.29.6.776.

Congenital Non-Neural Granular Cell Tumor Mimicking Nevus Lipomatosus Superficialis

• Park JY
• Kwon WJ
• Park BW
• Cho EB
• Park EJ
• Kim KH
• Kim KJ

• KMID: 2395187
• DOI: http://doi.org/10.5021/ad.2017.29.6.776

Abstract

A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS.

Keyword

CD68; Granular cell tumor; Nevus lipomatosus superficialis; S100 proteins; Vimentin

MeSH Terms

Biopsy
Child
Coloring Agents
Cytoplasm
Forearm
Granular Cell Tumor*
Humans
Infant
Nevus*
Parturition
S100 Proteins
Vimentin
Coloring Agents
S100 Proteins
Vimentin

Figure

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  Fig. 1 Localized, grouped, skin-colored to erythematous, polygonal, soft nodules on the right forearm.

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  Fig. 2 (A, B) Diffuse infiltrate of monomorphic tumor cells in the dermis (H&E; A: ×100, B: ×200). (C) Large, polygonal tumor cells (arrows) with abundant granular cytoplasm (×400). (D, E) Immunohistochemical stainings revealed showing strong positivity for CD68 and vimentin (×200, respectively). (F, G) Immunohistochemical stain for S-100 and SMA were negative (S-100, ×200; SMA, ×100). (H) Periodic acid Schiff (PAS) highlights cytoplasmic granules after diastase digestion (PAS, ×400).

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