Ann Dermatol.  2017 Apr;29(2):234-236. 10.5021/ad.2017.29.2.234.

The Concept of Onychodermis (Specialized Nail Mesenchyme) Is Applicable in Normal Adult Nail Unit

• Park JH
• Lee DY
• Ha SY
• Jang KT
• Kwon GY
• Lee KH
• Shim JS

• KMID: 2394853
• DOI: http://doi.org/10.5021/ad.2017.29.2.234

Abstract

No abstract available.

MeSH Terms

Adult*
Humans

Figure

• 

  Fig. 1 H&E staining in the longitudinal section of normal adult nail unit. (A) Low-power view (×20). (B, C) High power view of nail bed area and nail matrix area respectively (×200).

• 

  Fig. 2 Immunohistochemical staining of CD10 in the longitudinal section of normal adult nail unit. (A) Low-power view (×40). (B, C) High power view of nail bed area and nail matrix area respectively (×200).

Reference

1. Lee KJ, Kim WS, Lee JH, Yang JM, Lee ES, Mun GH, et al. CD10, a marker for specialized mesenchymal cells (onychofibroblasts) in the nail unit. J Dermatol Sci. 2006; 42:65–67.

2. Lee DY, Yang JM, Mun GH, Jang KT, Cho KH. Immunohistochemical study of specialized nail mesenchyme containing onychofibroblasts in transverse sections of the nail unit. Am J Dermatopathol. 2011; 33:266–270.

3. Lee DY, Park JH, Shin HT, Yang JM, Jang KT, Kwon GY, et al. The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study. Histopathology. 2012; 61:123–130.

4. Lee DY, Park JH, Shin HT, Jang KT, Kwon GY, Shim JS. Onychodermis (specialized nail mesenchyme) containing onychofibroblasts in horizontal sections of the nail unit. Br J Dermatol. 2012; 166:1127–1129.

5. Sellheyer K, Nelson P. The concept of the onychodermis (specialized nail mesenchyme): an embryological assessment and a comparative analysis with the hair follicle. J Cutan Pathol. 2013; 40:463–471.

6. Park JH, Lee DY. CD10 is expressed in nail mesenchyme (onychodermis) containing onychofibroblasts of the adult nail unit. Clin Exp Dermatol. 2012; 37:685–686.

7. Perrin C. The nail dermis: from microanatomy to constitutive modelling. Histopathology. 2015; 66:864–872.

8. Lee KJ, Choi YL, Kim WS, Lee JH, Yang JM, Lee ES, et al. CD10 is expressed in dermal sheath cells of the hair follicles in human scalp. Br J Dermatol. 2006; 155:858–860.

9. Okazaki M, Yoshimura K, Fujiwara H, Suzuki Y, Harii K. Induction of hard keratin expression in non-nail-matrical keratinocytes by nail-matrical fibroblasts through epithelial-mesenchymal interactions. Plast Reconstr Surg. 2003; 111:286–290.

10. Lee DY. The relation of onychomatricoma to onychodermis in the nail unit. Ann Dermatol. 2013; 25:394–395.