Ann Dermatol.  2017 Apr;29(2):232-233. 10.5021/ad.2017.29.2.232.

Granulocyte Colony-Stimulating Factor-Induced Psoriasiform Dermatitis Improved by Narrowband Ultraviolet B

• Jang MS
• Park JB
• Kim JH
• Yang MH
• Lee KH
• Han SH
• Suh KS

• KMID: 2394852
• DOI: http://doi.org/10.5021/ad.2017.29.2.232

Abstract

No abstract available.

MeSH Terms

Dermatitis*
Granulocytes*

Figure

• 

  Fig. 1 (A) Generalized erythematous scaly papules and patches on the whole body. (B) Clinical photographs taken one week after 19 cycles of narrowband ultraviolet B phototherapy. There is significant improvement in the skin lesions from the initial presentation, especially on the trunk. (C) Histopathologic findings showed epidermal acanthosis, confluent parakeratosis, neutrophils in the stratum corneum (Munro's microabscess), and dilated capillaries in the dermal papillae (H&E, ×200).

Reference

1. Asnis LA, Gaspari AA. Cutaneous reactions to recombinant cytokine therapy. J Am Acad Dermatol. 1995; 33:393–410.

2. Mössner R, Beckmann I, Hallermann C, Neumann C, Reich K. Granulocyte colony-stimulating-factor-induced psoriasiform dermatitis resembles psoriasis with regard to abnormal cytokine expression and epidermal activation. Exp Dermatol. 2004; 13:340–346.

3. Watanabe T, Kawano Y, Kanamaru S, Onishi T, Kaneko S, Wakata Y, et al. Endogenous interleukin-8 (IL-8) surge in granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Blood. 1999; 93:1157–1163.

4. Rácz E, Prens EP, Kurek D, Kant M, de Ridder D, Mourits S, et al. Effective treatment of psoriasis with narrow-band UVB phototherapy is linked to suppression of the IFN and Th17 pathways. J Invest Dermatol. 2011; 131:1547–1558.

5. Ozawa M, Ferenczi K, Kikuchi T, Cardinale I, Austin LM, Coven TR, et al. 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions. J Exp Med. 1999; 189:711–718.