Korean J Obstet Gynecol.  2012 Oct;55(10):756-760.

A case of juvenile xanthogranuloma involving skin and multiple systemic organs in a fetus

• Kim E
• Kim HY
• Lee JH
• Park CW
• Park JS
• Jun JK

Abstract

Juvenile xanthogranuloma is a benign histiocytic proliferative disorder. It typically presents as a solitary, benign, rapidly growing cutaneous tumor that may regress spontaneously. Most of juvenile xanthogranuloma occur in infants and young children. We had experienced a case of juvenile xanthogranuloma in a fetus which involves multiple systemic organs. On prenatal ultrasonography, the fetus presented with pulmonary, perineal and hepatic nodules. The neonate was diagnosed with juvenile xanthogranuloma by the cutaneous and perineal nodule biopsy after birth. The neonate outpatient follow-up shows spontaneous regression without specific treatment. So we report a case with a brief review of the literature.

Keyword

Juvenile xanthogranuloma; Fetus; Systemic involvement; Multiple; Congenital

MeSH Terms

Biopsy
Fetus
Follow-Up Studies
Humans
Infant
Infant, Newborn
Outpatients
Parturition
Skin
Ultrasonography, Prenatal
Xanthogranuloma, Juvenile

Figure

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  Fig. 1 Prenatal ultrasonographic findings, showing multiple neoplastic masses in lung (A, B), liver (C) and perineum (D).

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  Fig. 2 Perineal mass, after birth.

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  Fig. 3 Sonographic findings of liver masses, after birth (A, B), and after regression (C).

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