J Pathol Transl Med.  2017 May;51(3):335-340. 10.4132/jptm.2016.07.24.

Cerebellar Liponeurocytoma: Relevant Clinical Cytogenetic Findings

• Tucker A
• Boon-Unge
• McLaughlin N
• Ibrahim H
• Rao N
• Martin N
• Everson R
• Khanlou N

• KMID: 2392603
• DOI: http://doi.org/10.4132/jptm.2016.07.24

Abstract

No abstract available.

MeSH Terms

Cytogenetics*

Figure

• 

  Fig. 1. Radiographic and gross appearance. Magnetic resonance imaging of heterogeneously-enhancing right cerebellar hemisphere mass. Axial T1-weighted precontrast (A), T1-weighted postcontrast (B), T2-weighted (C), and fluid attenuated inversion recovery (D) images through the posterior fossa. Intraoperative photograph of tumor and surrounding cerebellum (E).

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  Fig. 2. Hematoxylin and eosin staining. (A) Areas of dense cellularity and scattered prominent vascular channels. (B) Oligodendroglial-like areas demonstrating cells with distinct perinuclear halos and a chicken wire vascular pattern. (C) Region of palisading tumor nuclei reminiscent of ependymoma. (D) Foci of lipidized cells.

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  Fig. 3. Immunohistochemistry and fluorescent in-situ hybridization. (A) Diffuse synaptophysin immunoreactivity within the tumor. (B) Reactive gliosis on glial fibrillary acidic protein immunohistochemistry, but no tumor immunoreactivity. (C) Low Ki-67 nuclear labeling index, estimated at 3%–5%. (D) Fluorescent in-situ hybridization demonstrating lack of epidermal growth factor receptor (EGFR) amplification or MYC rearrangement.

Reference

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