J Korean Endocr Soc.  2006 Dec;21(6):506-514.

Effect of Weight Loss on Endothelial Function in Obese Premenopausal Women

• Ma SW
• Kim SH
• Nam HS
• Jung KM
• Yu BH
• Lee YJ
• Park SO
• Lim SK

Abstract

BACKGROUND: Endothelial dysfunction, a pathological feature of obesity, can predict the occurrence of cardiovascular disease. The endothelial function was compared in obese, non-obese, and type 2 diabetic women, and the effect of weight loss on endothelial function in obese premenopausal women was also investigated.
METHODS
Twenty type 2 diabetes patients, 35 obese and 20 non-obese non-diabetic subjects were recruited. Both the endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIV) were measured. The body composition, serum lipid, serum adiponectin and resistin were also measured. Weight loss in obese women was obtained by 6 months of calorific restriction, aerobic exercise and medication (sibutramine or orlistat).
RESULTS
EDV was significantly impaired in the type 2 diabetes and obese groups compared to the control group (6.0 +/- 1.3% in diabetes group, 6.7 +/- 3.9% in obese group, 12.4 +/- 4.1% in control group, P < 0.01, respectively). The mean weight loss after 6 months was 8.5 +/- 3.2 kg (P < 0.001) in the obese group. There was a significant increase in EDV after weight loss (from 5.8 +/- 3.5% to 12.3 +/- 3.9%, P < 0.05). There was no change in EIV after weight loss. In addition, weight loss was associated with significant reductions in the levels of high-sensitivity C-reactive protein (hs-CRP) and serum triglyceride (P < 0.05, respectively). However, there were no significant changes in the serum adiponectin and resistin levels after weight loss.
CONCLUSIONS
Our data demonstrated that weight loss was associated with improved endothelial function in obese premenopausal women, as assessed by brachial artery EDV and reduced hs-CRP.

Keyword

Adipocytokine; Endothelium-dependent vasodilation; Endothelium-independent vasodilation; Obesity; Weight loss

MeSH Terms

Adiponectin
Body Composition
Brachial Artery
C-Reactive Protein
Cardiovascular Diseases
Exercise
Female
Humans
Obesity
Resistin
Triglycerides
Vasodilation
Weight Loss*
Adiponectin
C-Reactive Protein
Resistin

Figure

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  Fig. 1 Baseline serum adiponectin (A) and resistin (B) concentration in non-obese, obese and diabetic women. Results are expressed as the mean ± SD. *P < 0.01; †P < 0.05.

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  Fig. 2 Endothelium-dependent (A) and endothelium-independent (B) vasodilation in non-obese, obese and diabetic women. EDV, endothelium-dependent vasodiation; EIV, endothelium-independent vasodilation. *P < 0.01.

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  Fig. 3 Effect of weight loss in endothelial function of obese women. EDV, endothelium-dependent vasodilation; EIV, endothelium-independent vasodilation. *P < 0.05.

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