Korean J Dermatol.  2017 Aug;55(7):394-400.

Clinical Manifestations and Genotypes of Human Papillomavirus in Korean Patients with Condyloma Acuminatum

Affiliations
  • 1Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea. yuhjoon@hanyang.ac.kr

Abstract

BACKGROUND
Condyloma acuminatum is a sexually transmitted disease (STD) associated with the human papillomavirus (HPV). Although it is a relatively common disease, there has been no epidemiological and clinical study of condyloma acuminatum performed in Korea since 1978.
OBJECTIVE
We aimed to evaluate the clinical features of condyloma acuminatum in Korean patients, to identify the genotypes of HPV, as well as determine factors associated with recurrence of condyloma acuminatum.
METHODS
We studied 80 patients (60 men and 20 women) diagnosed with condyloma acuminatum. We analyzed age, sex, duration of the disease, number and locations of lesions, underlying diseases and co-infection with STDs, treatment modalities, and number of relapses. Additionally, 26 patients were analyzed for HPV subtypes. We also evaluated factors affecting recurrence of condyloma.
RESULTS
Mean age at the time of diagnosis was 36.9±17.7 years and mean duration of disease was 7.2±16.5 months. The most common sites of involvement were found to be the penile shaft in men and the labia majora in women. We observed that 28 patients showed relapse with a mean duration of 1.5±4.5 months. HPV genotyping revealed that type 6, 11, and 44 genotypes that are associated with a low risk of malignancy were detected in 76.9% of cases, and type 16, 18, 51, 52, and 66 genotypes associated with a high risk of malignancy were detected in 15.3% cases. A significant relationship was observed between the recurrence rates of condyloma acuminatum and the rates of co-infection with STDs and the number of lesions.
CONCLUSION
We report a recent epidemiological and clinical review analyzing genotypes of HPV in Korean patients presenting with condyloma acuminatum.

Keyword

Condyloma acuminatum; Human papillomavirus

MeSH Terms

Clinical Study
Coinfection
Diagnosis
Female
Genotype*
Humans*
Korea
Male
Recurrence
Sexually Transmitted Diseases
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