J Dent Anesth Pain Med.  2017 Sep;17(3):163-181. 10.17245/jdapm.2017.17.3.163.

Perioperative red blood cell transfusion in orofacial surgery

• Park SY
• Seo KS
• Karm MH

• KMID: 2390801
• DOI: http://doi.org/10.17245/jdapm.2017.17.3.163

Abstract

In the field of orofacial surgery, a red blood cell transfusion (RBCT) is occasionally required during double jaw and oral cancer surgery. However, the question remains whether the effect of RBCT during the perioperative period is beneficial or harmful. The answer to this question remains challenging. In the field of orofacial surgery, transfusion is performed for the purpose of oxygen transfer to hypoxic tissues and plasma volume expansion when there is bleeding. However, there are various risks, such as infectious complications (viral and bacterial), transfusion-related acute lung injury, ABO and non-ABO associated hemolytic transfusion reactions, febrile non-hemolytic transfusion reactions, transfusion associated graft-versus-host disease, transfusion associated circulatory overload, and hypersensitivity transfusion reaction including anaphylaxis and transfusion-related immune-modulation. Many studies and guidelines have suggested RBCT is considered when hemoglobin levels recorded are 7 g/dL for general patients and 8-9 g/dL for patients with cardiovascular disease or hemodynamically unstable patients. However, RBCT is occasionally an essential treatment during surgeries and it is often required in emergency cases. We need to comprehensively consider postoperative bleeding, different clinical situations, the level of intra- and postoperative patient monitoring, and various problems that may arise from a transfusion, in the perspective of patient safety. Since orofacial surgery has an especially high risk of bleeding due to the complex structures involved and the extensive vascular distribution, measures to prevent bleeding should be taken and the conditions for a transfusion should be optimized and appropriate in order to promote patient safety.

Keyword

Orofacial Surgery; Red Blood Cell; Transfusion

MeSH Terms

Acute Lung Injury
Anaphylaxis
Cardiovascular Diseases
Emergencies
Erythrocyte Transfusion*
Erythrocytes*
Graft vs Host Disease
Hemorrhage
Humans
Hypersensitivity
Jaw
Monitoring, Physiologic
Mouth Neoplasms
Oxygen
Patient Safety
Perioperative Period
Plasma Volume
Transfusion Reaction
Oxygen

Reference

1. Vamvakas EC, Blajchman MA. Transfusion-related mortality: The ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood. 2009; 113:3406–3417. PMID: 19188662.

2. Goodnough LT, Levy JH, Murphy MF. Concepts of blood transfusion in adults. Lancet. 2013; 381:1845–1854. PMID: 23706801.

3. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, et al. Anemia and blood transfusion in critically ill patients. JAMA. 2002; 288:1499–1507. PMID: 12243637.

4. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, et al. The crit study: Anemia and blood transfusion in the critically ill--current clinical practice in the united states. Crit Care Med. 2004; 32:39–52. PMID: 14707558.

5. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in european intensive care units: Results of the soap study. Crit Care Med. 2006; 34:344–353. PMID: 16424713.

6. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion requirements in critical care investigators, canadian critical care trials group. N Engl J Med. 1999; 340:409–417. PMID: 9971864.

7. Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, et al. The premature infants in need of transfusion (pint) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr. 2006; 149:301–307. PMID: 16939737.

8. Hajjar LA, Vincent JL, Galas FR, Nakamura RE, Silva CM, Santos MH, et al. Transfusion requirements after cardiac surgery: The tracs randomized controlled trial. JAMA. 2010; 304:1559–1567. PMID: 20940381.

9. Schmidt PJ, Ness PM. Hemotherapy: From bloodletting magic to transfusion medicine. Transfusion. 2006; 46:166–168. PMID: 16441589.

10. Valeri CR, Khuri S, Ragno G. Role of the hct in the treatment of thrombocytopenic patients. Transfusion. 2003; 43:1761–1763. author reply 3. PMID: 14674376.

11. Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, et al. Clot contraction: Compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin. Blood. 2014; 123:1596–1603. PMID: 24335500.

12. Perioperative red cell transfusion. Natl Inst Health Consens Dev Conf Consens Statement. 1988; 7:1–6.

13. Sharma S, Sharma P, Tyler LN. Transfusion of blood and blood products: Indications and complications. Am Fam Physician. 2011; 83:719–724. PMID: 21404983.

14. Hogshire L, Carson JL. Red blood cell transfusion: What is the evidence when to transfuse? Curr Opin Hematol. 2013; 20:546–551. PMID: 23945271.

15. Liumbruno GM, Vaglio S, Biancofiore G, Marano G, Mengoli C, Franchini M. Transfusion thresholds and beyond. Blood Transfus. 2016; 14:123–125. PMID: 26950940.

16. Freedman J. Transfusion--whence and why. Transfus Apher Sci. 2014; 50:5–9. PMID: 24393629.

17. Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014; 371:1381–1391. PMID: 25270275.

18. Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013; 368:11–21. PMID: 23281973.

19. Jairath V, Kahan BC, Gray A, Dore CJ, Mora A, James MW, et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (trigger): A pragmatic, open-label, cluster randomised feasibility trial. Lancet. 2015; 386:137–144. PMID: 25956718.

20. Carson JL, Terrin ML, Noveck H, Sanders DW, Chaitman BR, Rhoads GG, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med. 2011; 365:2453–2462. PMID: 22168590.

21. Rohde JM, Dimcheff DE, Blumberg N, Saint S, Langa KM, Kuhn L, et al. Health care-associated infection after red blood cell transfusion: A systematic review and meta-analysis. JAMA. 2014; 311:1317–1326. PMID: 24691607.

22. Simon TL, Alverson DC, AuBuchon J, Cooper ES, DeChristopher PJ, Glenn GC, et al. Practice parameter for the use of red blood cell transfusions: Developed by the red blood cell administration practice guideline development task force of the college of american pathologists. Arch Pathol Lab Med. 1998; 122:130–138. PMID: 9499355.

23. Management ASoATFoPB. Practice guidelines for perioperative blood management: An updated report by the american society of anesthesiologists task force on perioperative blood management. Anesthesiology. 2015; 122:241–275. PMID: 25545654.

24. Liumbruno GM, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the transfusion management of patients in the peri-operative period. Iii. The post-operative period. Blood Transfus. 2011; 9:320–335. PMID: 21627922.

25. Napolitano LM, Kurek S, Luchette FA, Anderson GL, Bard MR, Bromberg W, et al. Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. J Trauma. 2009; 67:1439–1442. PMID: 20009700.

26. Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, et al. Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med. 2009; 37:3124–3157. PMID: 19773646.

27. Ferraris VA, Brown JR, Despotis GJ, Hammon JW, Reece TB, Saha SP, et al. 2011 update to the society of thoracic surgeons and the society of cardiovascular anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011; 91:944–982. PMID: 21353044.

28. Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012; 107:345–360. quiz 61. PMID: 22310222.

29. Alexander J, Cifu AS. Transfusion of red blood cells. JAMA. 2016; 316:2038–2039. PMID: 27732722.

30. Centre NCG. Acute upper gastrointestinal bleeding. (evidence update august 2014. A summary of selected new evidence relevant to nice clinical guideline 141. Evidence update 63). London: Royal College of Physicians;2012.

31. Excellence TNIfHaC. Blood transfusion nice guideline. Accessed on 31/03/2017. Available at: https://wwwniceorguk/guidance/ng24.

32. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, Aldecoa C, Barauskas G, et al. Management of severe perioperative bleeding: Guidelines from the european society of anaesthesiology: First update 2016. Eur J Anaesthesiol. 2017; 34:332–395. PMID: 28459785.

33. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, et al. Esc guidelines for the management of acute coronary syndromes in patients presenting without persistent st-segment elevation: The task force for the management of acute coronary syndromes (acs) in patients presenting without persistent st-segment elevation of the european society of cardiology (esc). Eur Heart J. 2011; 32:2999–3054. PMID: 21873419.

34. Qaseem A, Humphrey LL, Fitterman N, Starkey M, Shekelle P. Treatment of anemia in patients with heart disease: A clinical practice guideline from the american college of physicians. Ann Intern Med. 2013; 159:770–779. PMID: 24297193.

35. Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, et al. Clinical practice guidelines from the aabb: Red blood cell transfusion thresholds and storage. JAMA. 2016; 316:2025–2035. PMID: 27732721.

36. Berkow L, Rotolo S, Mirski E. Continuous noninvasive hemoglobin monitoring during complex spine surgery. Anesth Analg. 2011; 113:1396–1402. PMID: 21965372.

37. Miller RD, Ward TA, Shiboski SC, Cohen NH. A comparison of three methods of hemoglobin monitoring in patients undergoing spine surgery. Anesth Analg. 2011; 112:858–863. PMID: 21385985.

38. Kim SH, Choi JM, Kim HJ, Choi SS, Choi IC. Continuous noninvasive hemoglobin measurement is useful in patients undergoing double-jaw surgery. J Oral Maxillofac Surg. 2014; 72:1813–1819. PMID: 24813777.

39. Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med. 2008; 36:2667–2674. PMID: 18679112.

40. Perkins HA, Busch MP. Transfusion-associated infections: 50 years of relentless challenges and remarkable progress. Transfusion. 2010; 50:2080–2099. PMID: 20738828.

41. Hourfar MK, Jork C, Schottstedt V, Weber-Schehl M, Brixner V, Busch MP, et al. Experience of german red cross blood donor services with nucleic acid testing: Results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis c virus, and hepatitis b virus. Transfusion. 2008; 48:1558–1566. PMID: 18466173.

42. Lindholm PF, Annen K, Ramsey G. Approaches to minimize infection risk in blood banking and transfusion practice. Infect Disord Drug Targets. 2011; 11:45–56. PMID: 21303341.

43. Ziemann M, Thiele T. Transfusion-transmitted cmv infection - current knowledge and future perspectives. Transfus Med. 2017; 27:238–248. PMID: 28643867.

44. Sharma AD, Slaughter TF, Clements FM, Sreeram G, Newman MF, Phillips-Bute B, et al. Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery. Surg Infect (Larchmt). 2002; 3:127–133. PMID: 12519479.

45. Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, et al. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion. 2014; 54:137–148. PMID: 23721209.

46. Connell NT. Transfusion medicine. Prim Care. 2016; 43:651–659. PMID: 27866583.

47. Webert KE, Blajchman MA. Transfusion-related acute lung injury. Transfus Med Rev. 2003; 17:252–262. PMID: 14571393.

48. Bux J. Antibody-mediated (immune) transfusion-related acute lung injury. Vox Sang. 2011; 100:122–128. PMID: 21175662.

49. Shaz BH, Stowell SR, Hillyer CD. Transfusion-related acute lung injury: From bedside to bench and back. Blood. 2011; 117:1463–1471. PMID: 20944069.

50. Adkinson NF Jr, Burks W, Busse WW, Holgate ST, Lemanske RF Jr, O'Hehir RE. Middleton's allergy principles & practice. 8th edition. Elsevier;2014. p. 1152.

51. Anani W, Triulzi D, Yazer MH, Qu L. Relative iga-deficient recipients have an increased risk of severe allergic transfusion reactions. Vox Sang. 2014; 107:389–392. PMID: 25220631.

52. Popovsky MA, Audet AM, Andrzejewski C Jr. Transfusion-associated circulatory overload in orthopedic surgery patients: A multi-institutional study. Immunohematology. 1996; 12:87–89. PMID: 15387748.

53. Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. 2010; 137:209–220. PMID: 20051407.

54. Muszynski JA, Spinella PC, Cholette JM, Acker JP, Hall MW, Juffermans NP, et al. Transfusion-related immunomodulation: Review of the literature and implications for pediatric critical illness. Transfusion. 2017; 57:195–206. PMID: 27696473.

55. Vamvakas EC, Blajchman MA. Transfusion-related immunomodulation (trim): An update. Blood Rev. 2007; 21:327–348. PMID: 17804128.

56. Blajchman MA. The clinical benefits of the leukoreduction of blood products. J Trauma. 2006; 60:S83–S90. PMID: 16763486.

57. van Twuyver E, Mooijaart RJ, ten Berge IJ, van der Horst AR, Wilmink JM, Kast WM, et al. Pretransplantation blood transfusion revisited. N Engl J Med. 1991; 325:1210–1213. PMID: 1922208.

58. Jensen LS, Andersen AJ, Christiansen PM, Hokland P, Juhl CO, Madsen G, et al. Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg. 1992; 79:513–516. PMID: 1611441.

59. Berezina TL, Zaets SB, Morgan C, Spillert CR, Kamiyama M, Spolarics Z, et al. Influence of storage on red blood cell rheological properties. J Surg Res. 2002; 102:6–12. PMID: 11792145.

60. Vamvakas EC. Possible mechanisms of allogeneic blood transfusion-associated postoperative infection. Transfus Med Rev. 2002; 16:144–160. PMID: 11941576.

61. Dzik WH. Apoptosis, tgf beta and transfusion-related immunosuppression: Biologic versus clinical effects. Transfus Apher Sci. 2003; 29:127–129. PMID: 12941349.

62. Silliman CC, Clay KL, Thurman GW, Johnson CA, Ambruso DR. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil nadph oxidase. J Lab Clin Med. 1994; 124:684–694. PMID: 7964126.

63. Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, et al. Recognition of lyso-phospholipids by human natural killer t lymphocytes. PLoS Biol. 2009; 7:e1000228. PMID: 19859526.

64. Coutant F, Perrin-Cocon L, Agaugue S, Delair T, Andre P, Lotteau V. Mature dendritic cell generation promoted by lysophosphatidylcholine. J Immunol. 2002; 169:1688–1695. PMID: 12165488.

65. Jin Y, Damaj BB, Maghazachi AA. Human resting cd16-, cd16+ and il-2-, il-12-, il-15- or ifn-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. Eur J Immunol. 2005; 35:2699–2708. PMID: 16078278.

66. Olofsson KE, Andersson L, Nilsson J, Bjorkbacka H. Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce pro-inflammatory cytokine production in macrophages. Biochem Biophys Res Commun. 2008; 370:348–352. PMID: 18371300.

67. Jacobi KE, Wanke C, Jacobi A, Weisbach V, Hemmerling TM. Determination of eicosanoid and cytokine production in salvaged blood, stored red blood cell concentrates, and whole blood. J Clin Anesth. 2000; 12:94–99. PMID: 10818321.

68. Gately S, Li WW. Multiple roles of cox-2 in tumor angiogenesis: A target for antiangiogenic therapy. Semin Oncol. 2004; 31:2–11.

69. Mulligan JK, Rosenzweig SA, Young MR. Tumor secretion of vegf induces endothelial cells to suppress t cell functions through the production of pge2. J Immunother. 2010; 33:126–135. PMID: 20145550.

70. Baratelli F, Lee JM, Hazra S, Lin Y, Walser TC, Schaue D, et al. Pge (2) contributes to tgf-beta induced t regulatory cell function in human non-small cell lung cancer. Am J Transl Res. 2010; 2:356–367. PMID: 20733946.

71. Soontrapa K, Honda T, Sakata D, Yao C, Hirata T, Hori S, et al. Prostaglandin e2-prostaglandin e receptor subtype 4 (ep4) signaling mediates uv irradiation-induced systemic immunosuppression. Proc Natl Acad Sci U S A. 2011; 108:6668–6673. PMID: 21460251.

72. Bilgin YM, Brand A. Transfusion-related immunomodulation: A second hit in an inflammatory cascade. Vox Sang. 2008; 95:261–271. PMID: 19138255.

73. Seghatchian J. Universal leucodepletion: An overview of some unresolved issues and the highlights of lessons learned. Transfus Apher Sci. 2003; 29:105–117. PMID: 12941346.

74. Baumgartner JM, Nydam TL, Clarke JH, Banerjee A, Silliman CC, McCarter MD. Red blood cell supernatant potentiates lps-induced proinflammatory cytokine response from peripheral blood mononuclear cells. J Interferon Cytokine Res. 2009; 29:333–338. PMID: 19441884.

75. Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, et al. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion. 2009; 49:2326–2334. PMID: 19624600.

76. Patel MB, Proctor KG, Majetschak M. Extracellular ubiquitin increases in packed red blood cell units during storage. J Surg Res. 2006; 135:226–232. PMID: 16926027.

77. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA. Cd4+cd25high regulatory cells in human peripheral blood. J Immunol. 2001; 167:1245–1253. PMID: 11466340.

78. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory t cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med. 2003; 197:403–411. PMID: 12591899.

79. Chen W, Frank ME, Jin W, Wahl SM. Tgf-beta released by apoptotic t cells contributes to an immunosuppressive milieu. Immunity. 2001; 14:715–725. PMID: 11420042.

80. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 2000; 405:85–90. PMID: 10811223.

81. Saas P, Bonnefoy F, Kury-Paulin S, Kleinclauss F, Perruche S. Mediators involved in the immunomodulatory effects of apoptotic cells. Transplantation. 2007; 84:S31–S34. PMID: 17632410.

82. Saas P, Angelot F, Bardiaux L, Seilles E, Garnache-Ottou F, Perruche S. Phosphatidylserine-expressing cell byproducts in transfusion: A pro-inflammatory or an anti-inflammatory effect? Transfus Clin Biol. 2012; 19:90–97. PMID: 22677430.

83. McDonald PP, Fadok VA, Bratton D, Henson PM. Transcriptional and translational regulation of inflammatory mediator production by endogenous tgf-beta in macrophages that have ingested apoptotic cells. J Immunol. 1999; 163:6164–6172. PMID: 10570307.

84. Opelz G, Terasaki PI. Improvement of kidney-graft survival with increased numbers of blood transfusions. N Engl J Med. 1978; 299:799–803. PMID: 357971.

85. Williams JG, Hughes LE. Effect of perioperative blood transfusion on recurrence of crohn's disease. Lancet. 1989; 2:131–133. PMID: 2567897.

86. Rizzo JD, Somerfield MR, Hagerty KL, Seidenfeld J, Bohlius J, Bennett CL, et al. Use of epoetin and darbepoetin in patients with cancer: 2007 american society of clinical oncology/american society of hematology clinical practice guideline update. J Clin Oncol. 2008; 26:132–149. PMID: 17954713.

87. Cata JP, Chukka V, Wang H, Feng L, Gottumukkala V, Martinez F, et al. Perioperative blood transfusions and survival in patients with non-small cell lung cancer: A retrospective study. BMC Anesthesiol. 2013; 13:42. PMID: 24228905.

88. Goubran HA, Kotb RR, Stakiw J, Emara ME, Burnouf T. Regulation of tumor growth and metastasis: The role of tumor microenvironment. Cancer Growth Metastasis. 2014; 7:9–18. PMID: 24926201.

89. De Oliveira GS Jr., Schink JC, Buoy C, Ahmad S, Fitzgerald PC, McCarthy RJ. The association between allogeneic perioperative blood transfusion on tumour recurrence and survival in patients with advanced ovarian cancer. Transfus Med. 2012; 22:97–103. PMID: 22151920.

90. Acheson AG, Brookes MJ, Spahn DR. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis. Ann Surg. 2012; 256:235–244. PMID: 22791100.

91. Vamvakas EC. Allogeneic blood transfusion and cancer recurrence: 20 years later. Transfusion. 2014; 54:2149–2153. PMID: 25212422.

92. Goubran HA, Burnouf T, Radosevic M, El-Ekiaby M. The platelet-cancer loop. Eur J Intern Med. 2013; 24:393–400. PMID: 23433737.

93. Goubran HA, Burnouf T, Stakiw J, Seghatchian J. Platelet microparticle: A sensitive physiological “fine tuning” balancing factor in health and disease. Transfus Apher Sci. 2015; 52:12–18. PMID: 25599988.

94. Goubran H, Sabry W, Kotb R, Seghatchian J, Burnouf T. Platelet microparticles and cancer: An intimate cross-talk. Transfus Apher Sci. 2015; 53:168–172. PMID: 26542350.

95. Drabsch Y, ten Dijke P. Tgf-beta signalling and its role in cancer progression and metastasis. Cancer Metastasis Rev. 2012; 31:553–568. PMID: 22714591.

96. Connolly EC, Freimuth J, Akhurst RJ. Complexities of tgf-beta targeted cancer therapy. Int J Biol Sci. 2012; 8:964–978. PMID: 22811618.

97. Morner ME, Edgren G, Martling A, Gunnarsson U, Egenvall M. Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a swedish cohort study. Int J Colorectal Dis. 2017; 32:223–232. PMID: 27770250.

98. Nathanson SD, Tilley BC, Schultz L, Smith RF. Perioperative allogeneic blood transfusions. Survival in patients with resected carcinomas of the colon and rectum. Arch Surg. 1985; 120:734–738. PMID: 2988481.

99. Weiden PL, Bean MA, Schultz P. Perioperative blood transfusion does not increase the risk of colorectal cancer recurrence. Cancer. 1987; 60:870–874. PMID: 3594405.

100. Donohue JH, Williams S, Cha S, Windschitl HE, Witzig TE, Nelson H, et al. Perioperative blood transfusions do not affect disease recurrence of patients undergoing curative resection of colorectal carcinoma: A mayo/north central cancer treatment group study. J Clin Oncol. 1995; 13:1671–1678. PMID: 7602357.

101. Wiig JN. [blood transfusion in cancer of the colon and rectum. Friend or foe of the surgeon? A review]. Tidsskr Nor Laegeforen. 1990; 110:503–507. PMID: 2408192.

102. Deleplanque G, Deleplanque P, Kraimps JL, Carretier M, Barbier J. [prognostic incidence of blood transfusion in 753 patients operated for colorectal adenocarcinoma]. Ann Chir. 1992; 46:584–591. PMID: 1456687.

103. Faenza A, Cunsolo A, Selleri S, Lucarelli S, Farneti PA, Gozzetti G. Correlation between plasma or blood transfusion and survival after curative surgery for colorectal cancer. Int Surg. 1992; 77:264–269. PMID: 1478807.

104. Chung M, Steinmetz OK, Gordon PH. Perioperative blood transfusion and outcome after resection for colorectal carcinoma. Br J Surg. 1993; 80:427–432. PMID: 8192723.

105. Steup WH, Hojo K, Moriya Y, Sugihara K, Mizuno S, Hermans J, et al. An analysis on the effect of blood transfusion on recurrence and survival in patients undergoing extended lymphadenectomy for colorectal cancer. Hepatogastroenterology. 1994; 41:253–259. PMID: 7959548.

106. Qiu L, Wang DR, Zhang XY, Gao S, Li XX, Sun GP, et al. Impact of perioperative blood transfusion on immune function and prognosis in colorectal cancer patients. Transfus Apher Sci. 2016; 54:235–241. PMID: 26780991.

107. Li XX, Meng J, Sun GP, Tang YX, Liang GF, Wang MF, et al. Effects of perioperative blood transfusion on the prognosis in hereditary and sporadic colon cancer. Biomarkers. 2015; 20:481–486. PMID: 26616149.

108. Kaneko M, Sasaki S, Ishimaru K, Terai E, Nakayama H, Watanabe T. The impact of perioperative allogeneic blood transfusion on survival in elderly patients with colorectal cancer. Anticancer Res. 2015; 35:3553–3558. PMID: 26026124.

109. Tartter PI. Blood transfusion and infectious complications following colorectal cancer surgery. Br J Surg. 1988; 75:789–792. PMID: 3167530.

110. Vamvakas EC, Carven JH, Hibberd PL. Blood transfusion and infection after colorectal cancer surgery. Transfusion. 1996; 36:1000–1008. PMID: 8937412.

111. Schiergens TS, Rentsch M, Kasparek MS, Frenes K, Jauch KW, Thasler WE. Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases. Dis Colon Rectum. 2015; 58:74–82. PMID: 25489697.

112. Hallet J, Tsang M, Cheng ES, Habashi R, Kulyk I, Hanna SS, et al. The impact of perioperative red blood cell transfusions on long-term outcomes after hepatectomy for colorectal liver metastases. Ann Surg Oncol. 2015; 22:4038–4045. PMID: 25752895.

113. Liu L, Wang Z, Jiang S, Shao B, Liu J, Zhang S, et al. Perioperative allogenenic blood transfusion is associated with worse clinical outcomes for hepatocellular carcinoma: A meta-analysis. PLoS One. 2013; 8:e64261. PMID: 23741309.

114. Asahara T, Katayama K, Itamoto T, Yano M, Hino H, Okamoto Y, et al. Perioperative blood transfusion as a prognostic indicator in patients with hepatocellular carcinoma. World J Surg. 1999; 23:676–680. PMID: 10390585.

115. Makino Y, Yamanoi A, Kimoto T, El-Assal ON, Kohno H, Nagasue N. The influence of perioperative blood transfusion on intrahepatic recurrence after curative resection of hepatocellular carcinoma. Am J Gastroenterol. 2000; 95:1294–1300. PMID: 10811342.

116. Sun C, Wang Y, Yao HS, Hu ZQ. Allogeneic blood transfusion and the prognosis of gastric cancer patients: Systematic review and meta-analysis. Int J Surg. 2015; 13:102–110. PMID: 25486261.

117. Fong Y, Karpeh M, Mayer K, Brennan MF. Association of perioperative transfusions with poor outcome in resection of gastric adenocarcinoma. Am J Surg. 1994; 167:256–260. PMID: 8135315.

118. Hyung WJ, Noh SH, Shin DW, Huh J, Huh BJ, Choi SH, et al. Adverse effects of perioperative transfusion on patients with stage iii and iv gastric cancer. Ann Surg Oncol. 2002; 9:5–12. PMID: 11829431.

119. Kosumi K, Baba Y, Harada K, Yoshida N, Watanabe M, Baba H. Perioperative blood transfusion, age at surgery, and prognosis in a database of 526 upper gastrointestinal cancers. Dig Surg. 2015; 32:445–453. PMID: 26550999.

120. Dresner SM, Lamb PJ, Shenfine J, Hayes N, Griffin SM. Prognostic significance of peri-operative blood transfusion following radical resection for oesophageal carcinoma. Eur J Surg Oncol. 2000; 26:492–497. PMID: 11016472.

121. Langley SM, Alexiou C, Bailey DH, Weeden DF. The influence of perioperative blood transfusion on survival after esophageal resection for carcinoma. Ann Thorac Surg. 2002; 73:1704–1709. PMID: 12078756.

122. Reeh M, Ghadban T, Dedow J, Vettorazzi E, Uzunoglu FG, Nentwich M, et al. Allogenic blood transfusion is associated with poor perioperative and long-term outcome in esophageal cancer. World J Surg. 2017; 41:208–215. PMID: 27730355.

123. Lim MC, Kim JY, Kim TH, Park S, Kong SY, Yoon JH, et al. Allogeneic blood transfusion given before radiotherapy is associated with the poor clinical outcome in patients with cervical cancer. Yonsei Med J. 2008; 49:993–1003. PMID: 19108024.

124. Santin AD, Bellone S, Parrish RS, Coke C, Dunn D, Roman J, et al. Influence of allogeneic blood transfusion on clinical outcome during radiotherapy for cancer of the uterine cervix. Gynecol Obstet Invest. 2003; 56:28–34. PMID: 12867765.

125. Linder BJ, Frank I, Cheville JC, Tollefson MK, Thompson RH, Tarrell RF, et al. The impact of perioperative blood transfusion on cancer recurrence and survival following radical cystectomy. Eur Urol. 2013; 63:839–845. PMID: 23332883.

126. Little AG, Wu HS, Ferguson MK, Ho CH, Bowers VD, Segalin A, et al. Perioperative blood transfusion adversely affects prognosis of patients with stage i non-small-cell lung cancer. Am J Surg. 1990; 160:630–632. discussion 3. PMID: 2174651.

127. Perisanidis C, Dettke M, Papadogeorgakis N, Schoppmann A, Mittlbock M, Kyzas PA, et al. Transfusion of allogenic leukocyte-depleted packed red blood cells is associated with postoperative morbidity in patients undergoing oral and oropharyngeal cancer surgery. Oral Oncol. 2012; 48:372–378. PMID: 22182932.

128. Karakida K, Aoki T, Ota Y, Yamazaki H, Otsuru M, Takahashi M, et al. Analysis of risk factors for surgical-site infections in 276 oral cancer surgeries with microvascular free-flap reconstructions at a single university hospital. J Infect Chemother. 2010; 16:334–339. PMID: 20809241.

129. Liu SA, Wong YK, Poon CK, Wang CC, Wang CP, Tung KC. Risk factors for wound infection after surgery in primary oral cavity cancer patients. Laryngoscope. 2007; 117:166–171. PMID: 17202947.

130. Taniguchi Y, Okura M. Prognostic significance of perioperative blood transfusion in oral cavity squamous cell carcinoma. Head Neck. 2003; 25:931–936. PMID: 14603453.

131. Szakmany T, Dodd M, Dempsey GA, Lowe D, Brown JS, Vaughan ED, et al. The influence of allogenic blood transfusion in patients having free-flap primary surgery for oral and oropharyngeal squamous cell carcinoma. Br J Cancer. 2006; 94:647–653. PMID: 16523195.

132. Chau JK, Harris JR, Seikaly HR. Transfusion as a predictor of recurrence and survival in head and neck cancer surgery patients. J Otolaryngol Head Neck Surg. 2010; 39:516–522. PMID: 20828514.

133. Ervens J, Marks C, Hechler M, Plath T, Hansen D, Hoffmeister B. Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: A prospective, single-blinded, randomized, controlled clinical study. Int J Oral Maxillofac Surg. 2010; 39:1168–1174. PMID: 20961738.

134. Choi WS, Samman N. Risks and benefits of deliberate hypotension in anaesthesia: A systematic review. Int J Oral Maxillofac Surg. 2008; 37:687–703. PMID: 18511238.

135. Varol A, Basa S, Ozturk S. The role of controlled hypotension upon transfusion requirement during maxillary downfracture in double-jaw surgery. J Craniomaxillofac Surg. 2010; 38:345–349. PMID: 19913434.

136. Zellin G, Rasmusson L, Palsson J, Kahnberg KE. Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: A retrospective study. J Oral Maxillofac Surg. 2004; 62:662–666. PMID: 15170275.

137. Sankar D, Krishnan R, Veerabahu M, Vikraman B. Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study. Int J Oral Maxillofac Surg. 2012; 41:713–717. PMID: 22340993.

138. Ramos E, Dalmau A, Sabate A, Lama C, Llado L, Figueras J, et al. Intraoperative red blood cell transfusion in liver transplantation: Influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl. 2003; 9:1320–1327. PMID: 14625833.

139. Engoren MC, Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ. Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg. 2002; 74:1180–1186. PMID: 12400765.

140. Kleczynski P, Dziewierz A, Bagienski M, Rzeszutko L, Sorysz D, Trebacz J, et al. Association between blood transfusions and 12-month mortality after transcatheter aortic valve implantation. Int Heart J. 2017; 58:50–55. PMID: 28077819.

141. Bursi F, Barbieri A, Politi L, Di Girolamo A, Malagoli A, Grimaldi T, et al. Perioperative red blood cell transfusion and outcome in stable patients after elective major vascular surgery. Eur J Vasc Endovasc Surg. 2009; 37:311–318. PMID: 19111480.

142. Weber EW, Slappendel R, Prins MH, van der Schaaf DB, Durieux ME, Strumper D. Perioperative blood transfusions and delayed wound healing after hip replacement surgery: Effects on duration of hospitalization. Anesth Analg. 2005; 100:1416–1421. table of contents. PMID: 15845698.

143. Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 u to 2 u packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009; 208:931–937. 7.e1–7.e2. discussion 8-9. PMID: 19476865.

144. Ferraris VA, Davenport DL, Saha SP, Austin PC, Zwischenberger JB. Surgical outcomes and transfusion of minimal amounts of blood in the operating room. Arch Surg. 2012; 147:49–55. PMID: 22250113.

145. de Almeida JP, Vincent JL, Galas FR, de Almeida EP, Fukushima JT, Osawa EA, et al. Transfusion requirements in surgical oncology patients: A prospective, randomized controlled trial. Anesthesiology. 2015; 122:29–38. PMID: 25401417.

146. Samman N, Cheung LK, Tong AC, Tideman H. Blood loss and transfusion requirements in orthognatic surgery. J Oral Maxillofac Surg. 1996; 54:21–24. discussion 5-6. PMID: 8530995.

147. Gong SG, Krishnan V, Waack D. Blood transfusions in bimaxillary orthognathic surgery: Are they necessary? Int J Adult Orthodon Orthognath Surg. 2002; 17:314–317. PMID: 12593003.

148. Ueki K, Marukawa K, Shimada M, Nakagawa K, Yamamoto E. The assessment of blood loss in orthognathic surgery for prognathia. J Oral Maxillofac Surg. 2005; 63:350–354. PMID: 15742286.

149. Stewart A, Newman L, Sneddon K, Harris M. Aprotinin reduces blood loss and the need for transfusion in orthognathic surgery. Br J Oral Maxillofac Surg. 2001; 39:365–370. PMID: 11601817.

150. Moenning JE, Bussard DA, Lapp TH, Garrison BT. Average blood loss and the risk of requiring perioperative blood transfusion in 506 orthognathic surgical procedures. J Oral Maxillofac Surg. 1995; 53:880–883. PMID: 7629615.

151. Kramer FJ, Baethge C, Swennen G, Teltzrow T, Schulze A, Berten J, et al. Intra- and perioperative complications of the lefort i osteotomy: A prospective evaluation of 1000 patients. J Craniofac Surg. 2004; 15:971–977. discussion 8-9. PMID: 15547385.

152. Flood TR, Ilankovan V, Moos KF, el-Attar A. Cross-match requirements in orthognathic surgery: An audit. Br J Oral Maxillofac Surg. 1990; 28:292–294. PMID: 2248935.

153. Tang ZL, Wang X, Yi B, Li ZL, Liang C, Wang XX. Effects of the preoperative administration of yunnan baiyao capsules on intraoperative blood loss in bimaxillary orthognathic surgery: A prospective, randomized, double-blind, placebo-controlled study. Int J Oral Maxillofac Surg. 2009; 38:261–266. PMID: 19153029.

154. Faverani LP, Ramalho-Ferreira G, Fabris AL, Polo TO, Poli GH, Pastori CM, et al. Intraoperative blood loss and blood transfusion requirements in patients undergoing orthognathic surgery. Oral Maxillofac Surg. 2014; 18:305–310. PMID: 23620250.

155. Garcia-Roa M, Del Carmen Vicente-Ayuso M, Bobes AM, Pedraza AC, Gonzalez-Fernandez A, Martin MP, et al. Red blood cell storage time and transfusion: Current practice, concerns and future perspectives. Blood Transfus. 2017; 15:222–231. PMID: 28518049.

156. Cancelas JA, Dumont LJ, Maes LA, Rugg N, Herschel L, Whitley PH, et al. Additive solution-7 reduces the red blood cell cold storage lesion. Transfusion. 2015; 55:491–498. PMID: 25233911.

157. Hess JR, Rugg N, Knapp AD, Gormas JF, Silberstein EB, Greenwalt TJ. Successful storage of rbcs for 9 weeks in a new additive solution. Transfusion. 2000; 40:1007–1011. PMID: 10960530.

158. Antonelou MH, Kriebardis AG, Papassideri IS. Aging and death signalling in mature red cells: From basic science to transfusion practice. Blood Transfus. 2010; 8(Suppl 3):s39–s47. PMID: 20606748.

159. Blasi B, D'Alessandro A, Ramundo N, Zolla L. Red blood cell storage and cell morphology. Transfus Med. 2012; 22:90–96. PMID: 22394111.

160. D'Alessandro A, D'Amici GM, Vaglio S, Zolla L. Time-course investigation of sagm-stored leukocyte-filtered red bood cell concentrates: From metabolism to proteomics. Haematologica. 2012; 97:107–115. PMID: 21993682.

161. Bosman GJ, Werre JM, Willekens FL, Novotny VM. Erythrocyte ageing in vivo and in vitro: Structural aspects and implications for transfusion. Transfus Med. 2008; 18:335–347. PMID: 19140816.

162. Hod EA, Godbey EA. The outsider adverse event in transfusion: Inflammation. Presse Med. 2016; 45:e325–e329. PMID: 27476779.

163. van de Watering L. Red cell storage and prognosis. Vox Sang. 2011; 100:36–45. PMID: 21175654.

164. Eikelboom JW, Cook RJ, Barty R, Liu Y, Arnold DM, Crowther MA, et al. Rationale and design of the informing fresh versus old red cell management (inform) trial: An international pragmatic randomized trial. Transfus Med Rev. 2016; 30:25–29. PMID: 26651419.

165. Shah A, McKechnie S, Brunskill SJ, Stanworth SJ. Fresh versus old red cell transfusions: What have the recent clinical trials found. Curr Opin Hematol. 2016; 23:550–556. PMID: 27518928.

166. Chalfin HJ, Frank SM, Feng Z, Trock BJ, Drake CG, Partin AW, et al. Allogeneic versus autologous blood transfusion and survival after radical prostatectomy. Transfusion. 2014; 54:2168–2174. PMID: 24601996.

167. Dietrich W, Thuermel K, Heyde S, Busley R, Berger K. Autologous blood donation in cardiac surgery: Reduction of allogeneic blood transfusion and cost-effectiveness. J Cardiothorac Vasc Anesth. 2005; 19:589–596. PMID: 16202891.

168. Heiss MM, Mempel W, Delanoff C, Jauch KW, Gabka C, Mempel M, et al. Blood transfusion-modulated tumor recurrence: First results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. J Clin Oncol. 1994; 12:1859–1867. PMID: 8083709.

169. Oh AY, Seo KS, Lee GE, Kim HJ. Effect of preoperative autologous blood donation on patients undergoing bimaxillary orthognathic surgery: A retrospective analysis. Int J Oral Maxillofac Surg. 2016; 45:486–489. PMID: 26678802.

170. Jakovina Blazekovic S, Bicanic G, Hrabac P, Tripkovic B, Delimar D. Pre-operative autologous blood donation versus no blood donation in total knee arthroplasty: A prospective randomised trial. Int Orthop. 2014; 38:341–346. PMID: 24305788.

171. Zhou J. A review of the application of autologous blood transfusion. Braz J Med Biol Res. 2016; 49:e5493. PMID: 27533770.

172. Practice guidelines for blood component therapy: A report by the american society of anesthesiologists task force on blood component therapy. Anesthesiology. 1996; 84:732–747. PMID: 8659805.

173. Bryson GL, Laupacis A, Wells GA. Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The international study of perioperative transfusion. Anesth Analg. 1998; 86:9–15. PMID: 9428843.

174. Barile L, Fominskiy E, Di Tomasso N, Alpizar Castro LE, Landoni G, De Luca M, et al. Acute normovolemic hemodilution reduces allogeneic red blood cell transfusion in cardiac surgery: A systematic review and meta-analysis of randomized trials. Anesth Analg. 2017; 124:743–752. PMID: 27669554.

175. Lee JM, Seo KS, Kim HJ, Shin SY. Experience of a bloodless two-jaw surgery and care in jehovah's witnesses with anemia. J Korean Dent Soc Anesthesiol. 2012; 12:25–31.

176. Ickx BE, Rigolet M, Van Der Linden PJ. Cardiovascular and metabolic response to acute normovolemic anemia. Effects of anesthesia. Anesthesiology. 2000; 93:1011–1016. PMID: 11020756.

177. Hill J, James V. Survey of autologous blood transfusion activity in england (2001). Transfus Med. 2003; 13:9–15. PMID: 12581449.

178. Ashworth A, Klein AA. Cell salvage as part of a blood conservation strategy in anaesthesia. Br J Anaesth. 2010; 105:401–416. PMID: 20802228.