J Menopausal Med.  2017 Aug;23(2):96-101. 10.6118/jmm.2017.23.2.96.

The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women

• Park BK
• Yun KY
• Kim SC
• Joo JK
• Lee KS
• Choi OH

• KMID: 2389224
• DOI: http://doi.org/10.6118/jmm.2017.23.2.96

Abstract

OBJECTIVES
The relationship between renal function and bone mineral density (BMD) is controversial. We evaluated the relationship between markers of renal function and BMD in healthy Korean women.
METHODS
A total of 1,093 women who visited the health promotion center at Pusan National University hospital were included in the cross-sectional study. We divided the study population into two groups by BMD: osteopenia-osteoporosis and normal in the lumbar and femur regions, respectively. We compared the relationship between renal function and BMD using a logistic regression model and used SAS 9.3 (SAS Institute, Inc., Cary, NC, USA) for all statistical analysis.
RESULTS
Blood urea nitrogen (BUN), creatinine, and cystatin C (Cys-C) were correlated with BMD in both the normal and osteopenia-osteoporosis groups, and in logistic regression analysis, BUN and Cys-C were correlated with lumbar and femur BMD. However, after we adjusted for age, menopause, and body mass index, only creatinine showed a negative correlation with lumbar BMD, and estimated glomerular filtration rate (eGFR) was related positively with femur BMD.
CONCLUSIONS
Serum creatinine could be a marker for lumbar BMD and eGFR for femur BMD in Korean women without overt nephropathy.

Keyword

Bone density; Creatinine; Cystatin C; Osteoporosis

MeSH Terms

Blood Urea Nitrogen
Body Mass Index
Bone Density
Bone Marrow*
Busan
Creatinine
Cross-Sectional Studies
Cystatin C
Female
Femur
Glomerular Filtration Rate
Health Promotion
Humans
Logistic Models
Menopause
Osteoporosis
Creatinine
Cystatin C

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