Ann Dermatol.  2017 Aug;29(4):503-506. 10.5021/ad.2017.29.4.503.

Two Cases of Successful Treatment of Refractory Chronic Inflammatory Skin Disease, Atopic Dermatitis and Psoriasis with Oral Alitretinoin

• Son JH
• Park SY
• Cho YS
• Byun YS
• Chung BY
• Cho HJ
• Kim HO
• Park CW

• KMID: 2388957
• DOI: http://doi.org/10.5021/ad.2017.29.4.503

Abstract

No abstract available.

MeSH Terms

Dermatitis, Atopic*
Psoriasis*
Skin Diseases*
Skin*

Figure

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  Fig. 1 (A~C) A 32-year-old man presented with itchy erythematous to brownish skin lesions on the neck, trunk, and the flexor surface of both extremities. (D, E) Microscopic examination showed a chronic inflammatory lesion with focal hyperkeratosis and parakeratosis. Irregularly acanthotic epidermis with spongiosis was observed. Mild perivascular inflammatory cell infiltration and dilated vessels were in the dermis (H&E; D: ×100, E: ×200). (F~I) After four months of treatment with oral alitretinoin (30 mg/day) and topical steroid (betamethasone dipropionate) with calcipotriol monohydrate, the skin lesions subsided.

• 

  Fig. 2 (A~F) A 69-year-old woman presented with diffuse scaly erythematous skin lesions on her whole body surface. (G, H) Focal separated stratum corneum and parakeratosis, including neutrophils and red blood cells, were observed (Munro microabscess). Acanthotic epidermis without granular layer was observed. Inflammatory cells infiltrated the epidermis. Dilated vessels were in the dermis (H&E; G: ×100, H: ×200). (I~M) Within five months of treatment with oral alitretinoin (30 mg/day) and topical steroid (betamethasone dipropionate) with calcipotriol monohydrate, skin lesions had been improved without noticeable adverse effect.

Reference

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