Ann Dermatol.  2017 Oct;29(5):635-637. 10.5021/ad.2017.29.5.635.

The Effect of FK 506 on the Reepithelialization of Superficial Skin Wound

Affiliations
  • 1Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea. shinam73@ hotmail.com
  • 2Department of Dermatology, Dankook University Medical College, Cheonan, Korea.

Abstract

No abstract available.


MeSH Terms

Skin*
Tacrolimus*
Wounds and Injuries*
Tacrolimus

Figure

  • Fig. 1 (A) Proliferation assay for tacrolimus (FK 506)-treated human outer root sheath keratinocytes (ORSKs) using Ez-cytox®. A dose dependent increase was detected but it was not statistically significant. Results are shown as mean±standard deviation (SD) of eight independent experiments. (B) ORSKs treated with FK 506 occupied up to 75.8%±5.5% of the initial gap, whereas the control cells were about 9.4%±1.6% (p<0.05). Results are shown as mean±SD of three independent experiments.

  • Fig. 2 (A) Transforming growth factor-beta (TGF-β1) was highly expressed 48 hours after treatment of human outer root sheath keratinocytes (ORSKs) with 104 nM tacrolimus (FK 506), whereas no change was detected in the control, 102 or 103 nM FK 506-treated groups. (B) No change in cytokeratin 6, 16, and 17 mRNA expression after ORSKs were treated with FK 506. CYP: cyclophilin A, KRT: cytokeratin.


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