J Korean Soc Clin Toxicol.  2017 Jun;15(1):40-46. 10.22537/jksct.2017.15.1.40.

The Usefulness of Serum Lipid Concentration as a Predictor of Convulsion in Patients with Glufosinate Ammonium Poisoning

• Lee HD
• Sun KH
• Kim SJ

• KMID: 2386864
• DOI: http://doi.org/10.22537/jksct.2017.15.1.40

Abstract

PURPOSE
Glufosinate ammonium (GA; phosphinothricin) can induce neurological complications such as altered mental status, amnesia, and convulsions. This study was conducted to evaluate whether blood lipid profiles can help predict convulsions in patients with GA poisoning.
METHODS
This study was a retrospective review of data acquired at a tertiary academic university hospital from March 2014 to July 2016. Independent t-test, Mann-Whitney test and Analysis of covariance (ANCOVA) of demographic and laboratory findings of 50 patients with GA poisoning were performed to identify correlations of general characteristics and laboratory findings, including blood lipid profiles of GA-poisoned patients between with and without convulsions.
RESULTS
Convulsion as a GA complication showed a significant association with poison volume, age, white blood cell count, and creatine phosphokinase (CK), albumin, lactate dehydrogenase (LDH), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) content in blood according to an independent t-test and Mann-Whitney test. However, ANCOVA demonstrated significant association with LDL and triglyceride.
CONCLUSION
Blood lipid profiles, especially serum LDL and triglyceride, were useful in predicting convulsions in patients with GA poisoning.

Keyword

Phosphinothricin; Neurologic manifestations; LDL; Triglyceride

MeSH Terms

Ammonium Compounds*
Amnesia
Creatine Kinase
Humans
L-Lactate Dehydrogenase
Leukocyte Count
Lipoproteins
Neurologic Manifestations
Poisoning*
Retrospective Studies
Seizures*
Triglycerides
Creatine Kinase
L-Lactate Dehydrogenase
Lipoproteins