J Korean Med Sci.  2017 Sep;32(9):1415-1422. 10.3346/jkms.2017.32.9.1415.

Cadmium Exposure Is Associated with Monocyte Count and Monocyte to HDL Ratio, a Marker of Inflammation and Future Cardiovascular Disease in the Male Population

• Baek K
• Chung I

• KMID: 2385946
• DOI: http://doi.org/10.3346/jkms.2017.32.9.1415

Abstract

Cadmium is a heavy metal that humans can be exposed to the in environment and occupation, and its relationship with cardiovascular diseases has been reported. in various reports. Epidemiological studies have also been associated with various inflammatory markers of cardiovascular diseases. In this study, we examined the relationship between monocyte count and monocyte to high density lipoprotein (HDL) ratio (MHR) and blood cadmium, which are one of the inflammatory markers of cardiovascular diseases. Data from a total of 733 male fire officers who received a health checkup at a hospital for one year in 2016 were analyzed. Populations were classified into 4 groups according to the quartile of blood cadmium and general characteristics were described. The relationship between monocyte count, MHR and cadmium in blood was statistically analyzed by linear regression analysis. In the univariate analysis and multivariate analysis, monocyte count was significantly higher in the second, third and fourth quartile groups than in the first quartile of cadmium, and the linear trend was significant. In univariate and multivariate analysis, MHR was significantly higher in the third and fourth quartile groups than in the first quartile group, and the linear trend was also significant. This study showed the significant relationship between blood cadmium and monocyte count and MHR among male fire officers. This was also statistically significant in the model adjusted for possible confounders and other cardiovascular risk factors and showed a linear trend.

Keyword

Cadmium; Cardiovascular Diseases; Cholesterol; HDL; Monocytes

MeSH Terms

Cadmium*
Cardiovascular Diseases*
Cholesterol
Epidemiologic Studies
Fires
Humans
Inflammation*
Linear Models
Lipoproteins
Male*
Monocytes*
Multivariate Analysis
Occupations
Risk Factors
Cadmium
Cholesterol
Lipoproteins

Figure

• 

  Fig. 1 Adjusted coefficient (95% CIs) for monocyte count (103/μL) associated with quartiles of blood cadmium level. The regression coefficient was adjusted by age, smoking, alcohol drinking, BMI, hypertension, diabetes, and hyperlipidemia. CI = confidence interval.

• 

  Fig. 2 Adjusted coefficient (95% CIs) for MHR associated with quartiles of blood cadmium level. The regression coefficient was adjusted by age, smoking, alcohol drinking, BMI, hypertension, diabetes, and hyperlipidemia. CI = confidence interval, MHR = monocyte to high density lipoprotein ratio, HDL = high density lipoprotein.

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