J Clin Neurol.  2016 Oct;12(4):495-501. 10.3988/jcn.2016.12.4.495.

Early Electrodiagnostic Features of Upper Extremity Sensory Nerves Can Differentiate Axonal Guillain-Barré Syndrome from Acute Inflammatory Demyelinating Polyneuropathy

Affiliations
  • 1Department of Neurology, Korea University Medical Center, Seoul, Korea. nukbj@korea.ac.kr
  • 2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
  • 4Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
  • 5Department of Neurology, Haeundae Paik Hospital, Inje University, Busan, Korea.
  • 6Department of Neurology, College of Medicine, Hallym University, Chunchoen, Korea.
  • 7Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 8Department of Neurology, Konkuk University Medical Center, Seoul, Korea.
  • 9Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Korea.

Abstract

BACKGROUND
AND PURPOSE: Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barré syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes.
METHODS
We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs. An antiganglioside antibody study was used to increase the diagnostic certainty.
RESULTS
The amplitudes of median and ulnar nerve sensory nerve action potentials (SNAPs) were significantly smaller in the AIDP group than in the axonal-GBS group. Classification and regression-tree analysis revealed that the distal ulnar sensory nerve SNAP amplitude was the best predictor of axonal GBS.
CONCLUSIONS
Early upper extremity sensory NCS findings are helpful in differentiating axonal-GBS patients with antiganglioside antibodies from AIDP patients.

Keyword

Guillain-Barré syndrome; acute inflammatory demyelinating polyneuropathy; early diagnosis; electrodiagnosis; neural conduction
Full Text Links
  • JCN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr