Clin Endosc.  2017 Mar;50(2):179-184. 10.5946/ce.2016.031.

Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study

• Kim SG
• Kim N
• Shin SK
• Sung IK
• Hong SJ
• Park HJ

• KMID: 2383535
• DOI: http://doi.org/10.5946/ce.2016.031

Abstract

BACKGROUND/AIMS
Long-term use of aspirin can be a risk factor of peptic ulcer diseases. The aim of this study was to evaluate the efficacy of Albis (Daewoong Pharmaceutical Co., Ltd.) for the prevention of gastric mucosal injury caused by aspirin.
METHODS
Aspirin users were enrolled and randomized into the Albis or placebo group. Screening and follow-up endoscopy were performed for modified Lanza scores (MLSs). Primary outcome was measured by the incidence rate of peptic ulcer, and secondary outcomes were measured by the incidence rate of gastritis, improvement in MLS and subjective symptoms.
RESULTS
In total, 81 aspirin users were randomized, 43 in the Albis group and 38 in the placebo group. There was no incidence of peptic ulcer in both groups. The incidence of gastritis was significantly higher in the placebo group (44.4% vs. 10.0%, p=0.003); however, the scores of mucosal edema, hyperemia and hemorrhage were not statistically different between the two groups (p>0.05). The frequency of subjective symptoms were more improved in the Albis group than in the placebo group (p=0.023).
CONCLUSIONS
The incidence of gastritis was lower in the group that received low-dose aspirin and Albis. The development of peptic ulcer due to long-term use of aspirin might be prevented with concomitant use of Albis.

Keyword

Peptic ulcer; Aspirin; Albis; Modified Lanza score

MeSH Terms

Aspirin*
Edema
Endoscopy
Follow-Up Studies
Gastritis
Hemorrhage
Hyperemia
Incidence
Mass Screening
Peptic Ulcer
Prospective Studies*
Risk Factors
Aspirin

Figure

• 

  Fig. 1. Flow of the study population. A total of 81 patients were enrolled and randomized to Albis (Daewoong Pharmaceutical Co., Ltd.) or placebo group. Thirty patients in Albis group and 27 patients in placebo group were analyzed in full analysis set (FAS).

• 

  Fig. 2. The incidence of gastric mucosal injury in terms of modified Lanza scores. The incidence of gastric mucosal injury was higher in the placebo group.

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