Korean J Gastroenterol.  2016 Nov;68(5):288-290. 10.4166/kjg.2016.68.5.288.

The Influence of Proton Pump Inhibitor Use on the Gut Microbiome

• Park CH
• Lee SK

• KMID: 2383509
• DOI: http://doi.org/10.4166/kjg.2016.68.5.288

Abstract

No abstract available.

MeSH Terms

Gastrointestinal Microbiome*
Proton Pumps*
Protons*
Proton Pumps
Protons

Reference

References

1. Moayyedi P, Talley NJ. Gastro-oesophageal reflux disease. Lancet. 2006; 367:2086–2100.

2. Othman F, Card TR, Crooks CJ. Proton pump inhibitor prescribing patterns in the UK: a primary care database study. Pharmacoepidemiol Drug Saf. 2016; 25:1079–1087.

3. Tleyjeh IM, Bin Abdulhak AA, Riaz M, et al. Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and metaanalysis. PLoS One. 2012; 7:e50836.

4. Masclee GM, Coloma PM, Kuipers EJ, Sturkenboom MC. Increased risk of microscopic colitis with use of proton pump inhibitors and non-steroidal anti-inflammatory drugs. Am J Gastroenterol. 2015; 110:749–759.

5. Lambert AA, Lam JO, Paik JJ, Ugarte-Gil C, Drummond MB, Crowell TA. Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and metaanalysis. PLoS One. 2015; 10:e0128004.

6. Imhann F, Bonder MJ, Vich Vila A, et al. Proton pump inhibitors affect the gut microbiome. Gut. 2016; 65:740–748.

7. Faleck DM, Salmasian H, Furuya EY, Larson EL, Abrams JA, Freedberg DE. Proton pump inhibitors do not increase risk for clostridium difficile infection in the intensive care unit. Am J Gastroenterol. 2016. DOI: doi:10.1038/ajg.2016.343. [Epub ahead of print].

8. Washio E, Esaki M, Maehata Y, et al. Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial. Clin Gastroenterol Hepatol. 2016; 14:809–815.e1.

9. Blackler RW, Gemici B, Manko A, Wallace JL. NSAID-gastro- enteropathy: new aspects of pathogenesis and prevention. Curr Opin Pharmacol. 2014; 19:11–16.

10. Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011; 141:1314–1322. 1322.e1–5.

11. McDonald EG, Milligan J, Frenette C, Lee TC. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med. 2015; 175:784–791.