J Korean Neuropsychiatr Assoc.  2014 Nov;53(6):418-425. 10.4306/jknpa.2014.53.6.418.

Impact of Delirium on Clinical Outcomes in Intensive Care Unit Patients: An Observational Study in a Korean General Hospital

Affiliations
  • 1Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
  • 2Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea. empathy@yuhs.ac
  • 3Department of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 4Department of Medical System Engineering (DMSE), Gwangju Institute of Science and Technology (GIST), Gwangju, Korea.
  • 5Department of Psychiatry, Severance Mental Health Hospital, Yonsei University College of Medicine, Gwangju, Korea.
  • 6Department of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
The purpose of this study is to evaluate the impact of delirium on clinical outcomes in intensive care unit (ICU) patients in a Korean general hospital.
METHODS
All patients admitted to ICU from March 1, 2013 to October 31, 2013 were assessed by Confusion Assessment Method adapted for use in the ICU for delirium daily, and consistently comatose patients were excluded for analysis. Differences in clinical outcomes (mortality, length of hospital stay, length of ICU stay) were analyzed between delirious patients and non-delirious patients. Subsequently, the impact of delirium on clinical outcomes was analyzed with adjusting for covariates including surgery, age, emergent admission, presence of surgery, and severity of illness.
RESULTS
The analysis included 129 delirious patients and 469 non-delirious patients. As primary outcome, mortality, length of stay (hospital day, ICU-stay) were significantly high in the delirious group. The association remained the same after adjusting for the covariates.
CONCLUSION
The results correspond with those of previous research studies conducted in foreign ICU. Based on this observation that delirium also has an impact on clinical outcomes in Korean ICU, integrative and in-depth investigation on ICU delirium will be needed.

Keyword

Intensive care unit; Delirium; Length of stay; Mortality; Clinical outcome

MeSH Terms

Coma
Delirium*
Hospitals, General*
Humans
Intensive Care Units*
Length of Stay
Mortality
Observational Study*

Figure

  • Fig. 1 Flow chart of inclusion for delirium study in ICU patients. ICU : Intensive care unit, RASS : Richmond Agitation-Sedation Scale.


Cited by  1 articles

Postoperative delirium
Seung-Taek Oh, Jin Young Park
Korean J Anesthesiol. 2019;72(1):4-12.    doi: 10.4097/kja.d.18.00073.1.


Reference

1. Zaal IJ, Slooter AJ. Delirium in critically ill patients: epidemiology, pathophysiology, diagnosis and management. Drugs. 2012; 72:1457–1471.
2. Girard TD, Shintani AK, Jackson JC, Gordon SM, Pun BT, Henderson MS, et al. Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care. 2007; 11:R28.
Article
3. Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med. 2001; 29:573–580.
Article
4. Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012; 367:30–39.
Article
5. Partridge JS, Martin FC, Harari D, Dhesi JK. The delirium experience: what is the effect on patients, relatives and staff and what can be done to modify this? Int J Geriatr Psychiatry. 2013; 28:804–812.
Article
6. Breitbart W, Gibson C, Tremblay A. The delirium experience: delirium recall and delirium-related distress in hospitalized patients with cancer, their spouses/caregivers, and their nurses. Psychosomatics. 2002; 43:183–194.
Article
7. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004; 291:1753–1762.
Article
8. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013; 41:263–306.
Article
9. Pulak LM, Jensen L. Sleep in the intensive care unit: a review. J Intensive Care Med. 2014; [Epub ahead of print].
10. Balas MC, Happ MB, Yang W, Chelluri L, Richmond T. Outcomes associated with delirium in older patients in surgical ICUs. Chest. 2009; 135:18–25.
Article
11. Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med. 2007; 35:112–117.
Article
12. Ely EW, Gautam S, Margolin R, Francis J, May L, Speroff T, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med. 2001; 27:1892–1900.
Article
13. Pun BT, Balas MC, Davidson J. Implementing the 2013 PAD guidelines: top ten points to consider. Semin Respir Crit Care Med. 2013; 34:223–235.
Article
14. Yu MY, Park JW, Hyun MS, Lee YJ. Factors related to delirium occurrence among the patients in the intensive care units. J Korean Clin Nurs Res. 2008; 14:151–160.
15. Lee EJ, Shim MY, Song SH, Lee M, Kim HM, Kang BS, et al. Risk factors related to delirium development in patients in surgical intensive care unit. J Korean Crit Care Nurs. 2010; 3:37–48.
16. van den Boogaard M, Schoonhoven L, Maseda E, Plowright C, Jones C, Luetz A, et al. Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. Intensive Care Med. 2014; 40:361–369.
Article
17. Lee JW, Lim SY. Burden and needs of the family members of the intensive care unit patients. J Korea Contents Assoc. 2014; 14:421–429.
Article
18. Lee HS, You MA, Lee SK, Son YJ. Factors influencing on burden of family members of intensive care patients: planned transfer to general ward after intensive care. J Korea Contents Assoc. 2014; 14:211–223.
Article
19. Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001; 29:1370–1379.
Article
20. van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ. 2012; 344:e420.
Article
21. Van Rompaey B, Elseviers MM, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care. 2009; 13:R77.
Article
22. LeGall JR, Loirat P, Alpérovitch A. APACHE II--a severity of disease classification system. Crit Care Med. 1986; 14:754–755.
Article
23. McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med. 2002; 162:457–463.
Article
24. Morandi A, Pandharipande P, Trabucchi M, Rozzini R, Mistraletti G, Trompeo AC, et al. Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients. Intensive Care Med. 2008; 34:1907–1915.
Article
25. Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med. 2007; 33:66–73.
Article
26. Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010; 38:1513–1520.
Article
27. Jones C, Bäckman C, Capuzzo M, Flaatten H, Rylander C, Griffiths RD. Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care. Intensive Care Med. 2007; 33:978–985.
Article
28. Drews T, Franck M, Radtke FM, Weiss B, Krampe H, Brockhaus WR, et al. Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient: a prospective observational study. Eur J Anaesthesiol. 2014; [Epub ahead of print].
29. Heymann A, Radtke F, Schiemann A, Lütz A, MacGuill M, Wernecke KD, et al. Delayed treatment of delirium increases mortality rate in intensive care unit patients. J Int Med Res. 2010; 38:1584–1595.
Article
30. American Psychiatric Association. Practice guideline for the treatment of patients with delirium. Am J Psychiatry. 1999; 156:5 Suppl. 1–20.
31. Young J, Murthy L, Westby M, Akunne A, O'Mahony R. Guideline Development Group. Diagnosis, prevention, and management of delirium: summary of NICE guidance. BMJ. 2010; 341:c3704.
Article
32. Martin J, Heymann A, Bäsell K, Baron R, Biniek R, Bürkle H, et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci. 2010; 8:Doc02.
33. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002; 30:119–141.
Article
34. Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001; 27:859–864.
Article
35. Luetz A, Heymann A, Radtke FM, Chenitir C, Neuhaus U, Nachtigall I, et al. Different assessment tools for intensive care unit delirium: which score to use? Crit Care Med. 2010; 38:409–418.
Article
36. Ouimet S, Riker R, Bergeron N, Cossette M, Kavanagh B, Skrobik Y. Subsyndromal delirium in the ICU: evidence for a disease spectrum. Intensive Care Med. 2007; 33:1007–1013.
Article
37. Chlan LL, Weinert CR, Heiderscheit A, Tracy MF, Skaar DJ, Guttormson JL, et al. Effects of patient-directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilatory support: a randomized clinical trial. JAMA. 2013; 309:2335–2344.
Article
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