Obstet Gynecol Sci.  2017 Jan;60(1):118-123. 10.5468/ogs.2017.60.1.118.

Lymphoepithelioma-like carcinoma of the uterine cervix

• Yun HS
• Lee SK
• Yoon G
• Kim HG
• Lee DH
• Na YJ
• Choi OH
• Shin DH
• Song YJ

• KMID: 2383219
• DOI: http://doi.org/10.5468/ogs.2017.60.1.118

Abstract

Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is exceedingly uncommon. We herein report a rare case of cervical LELC. A 45-year-old woman was admitted to gynecology department with vaginal bleeding for one month. Liquid-based cytology revealed atypical endometrial cells, not otherwise specified on her cervix. On a hysteroscopy, an endocervical mass was identified and the pathologic result was consistent with poorly differentiated squamous cell carcinoma. Magnetic resonance imaging and positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography revealed a 3.1-cm endocervical mass without distant metastasis or enlarged lymph nodes. The International Federation of Gynecology and Obstetrics stage was IB1. A radical hysterectomy and bilateral pelvic lymph node dissection were performed. The pathologic diagnosis was a poorly differentiated carcinoma, showing features of LELC. She has been followed for 8 months without adjuvant treatment since the surgery, during which time there has been no evidence of tumor recurrence or metastasis.

Keyword

Cervix uteri; Herpesvirus 4, human; Lymphoepithelioma-like carcinoma; Uterine cervical neoplasms

MeSH Terms

Carcinoma, Squamous Cell
Cervix Uteri*
Diagnosis
Female
Gynecology
Herpesvirus 4, Human
Humans
Hysterectomy
Hysteroscopy
Lymph Node Excision
Lymph Nodes
Magnetic Resonance Imaging
Middle Aged
Neoplasm Metastasis
Obstetrics
Positron-Emission Tomography
Recurrence
Uterine Cervical Neoplasms
Uterine Hemorrhage

Figure

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  Fig. 1 (A) Sagittal T2-weighted magnetic resonance imaging scan revealing a well-defined high signal intensity mass, 3.1 cm in size, at the anterior aspect of the endocervix, along with multiple uterine myomas less than 9 cm in size. (B) Macroscopically, the cervix was open at 12 o'clock. (C) The cells had large, ill-defined cytoplasmic borders, abundant cytoplasm, prominent nucleoli, and syncytial growth patterns (H&E, ×200). (D) Formalin fixed paraffin-embedded tissue used for in situ hybridization for Epstein-Barr virus–encoded early RNAs. The result was negative.

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