J Pathol Transl Med.  2015 Jan;49(1):78-80. 10.4132/jptm.2014.12.15.

A Rare Case of Tumor-to-Tumor Metastasis of Thyroid Papillary Carcinoma within a Pulmonary Adenocarcinoma

• Lee T
• Cha YJ
• Ahn S
• Han J
• Shim YM

• KMID: 2381358
• DOI: http://doi.org/10.4132/jptm.2014.12.15

Abstract

No abstract available.

MeSH Terms

Adenocarcinoma*
Carcinoma, Papillary*
Neoplasm Metastasis*
Thyroid Gland*

Figure

• 

  Fig. 1. Metastasis of thyroid papillary carcinoma within a pulmonary adenocarcinoma. (A) Chest computed tomography shows ground-glass opacity (white arrows) in the left upper lobe. Positron emission tomography reveals F-18 fluorodeoxyglucose uptake in the left lobe of the thyroid, multiple cervical lymph nodes and the left upper lung (black arrow). (B) Grossly, metastatic papillary thyroid carcinoma (PTC) is a small, round, firm, white-tan nodule (arrows) located within an irregular, soft, grey lung mass. (C) Under low-power magnification, metastatic PTC (arrows) is distinguished from background pulmonary adenocarcinoma by its localized and compact arrangement of tumor cells. (D) Metastatic PTC (arrows) exhibits a papillary growth pattern and less fibrosis compared to the predominant acinar pattern and large-scale fibrosis of pulmonary adenocarcinoma. (E) Together with well-formed papillae, tumor cells of metastatic PTC have typical nuclear features including nuclear clearing and grooves. (F) Three metastatic PTCs are strongly positive for thyroglobulin on immunohistochemistry.

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