J Pathol Transl Med.  2015 Jan;49(1):61-65. 10.4132/jptm.2014.09.17.

Mixed Carcinoid-Mucinous Adenocarcinoma Arising in Mature Teratoma of Mesentery

• Shin SJ
• Son EM
• Sung CO
• Kim KR

• KMID: 2381354
• DOI: http://doi.org/10.4132/jptm.2014.09.17

Abstract

No abstract available.

MeSH Terms

Adenocarcinoma*
Mesentery*
Teratoma*

Figure

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  Fig. 1. External appearance (A) and cut surface (B) of the mesenteric teratoma showing solid and cystic portions with yellow sebum-like materials in the cystic space of the mass. Arrow indicates mesenteric mass. Partially disrupted ovarian mass (C) showing multiple gelatinous tumor nodules on the surface and parenchyma (I, tumor implant; S, ovarian surface).

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  Fig. 2. Histopathologic findings of mesenteric mass showing mature cystic teratoma containing a mature teratomatous component (A, closed arrow), an area of trabecular carcinoid (A, open arrow), goblet cell carcinoid (B) showing immunopositivities for synaptophysin (B inset and C), and mucinous adenocarcinoma with signet ring cells within dissecting mucin pools (D). Note a high nuclear cytoplasmic ratio and significant nuclear pleomorphism in the mucinous adenocarcinoma component (D) in contrast to low nuclear cytoplasmic ratio and flattened nuclei in goblet cell carcinoid (B).

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  Fig. 3. Histopathologic findings of ovarian mass. The tumor tissue shows a multinodular appearance with well-circumscribed margins. Each nodule is composed of a mucin pool containing malignant tumor cells identical to those in the mesenteric mass (A). The tumor tissue in the ovarian surface and superficial cortex formed pseudomyxoma peritonei composed of mucin pools with floating signet ring cells, which are connected to the extraovarian mucin pools in the pelvic cavity (B).

Reference

1. Kurman RJ, Ronnett BM. Blaustein’s pathology of the female genital tract. 6th ed. New York: Springer;2011. p. 877.

2. Papakonstantinou E, Iavazzo C, Hasiakos D, Kleanthis CK, Fotiou S, Kondi-Pafiti A. Extraovarian mature cystic teratoma of the mesentery: a case report and literature review. Clin Exp Obstet Gynecol. 2011; 38:291–3.

3. Lancaster KJ, Liang CY, Myers JC, McCabe KM. Goblet cell carcinoid arising in a mature teratoma of the mediastinum. Am J Surg Pathol. 1997; 21:109–13.

4. Chetty R, Klimstra DS, Henson DE, Albores-Saavedra J. Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol. 2010; 34:1163–7.

5. Toumpanakis C, Standish RA, Baishnab E, Winslet MC, Caplin ME. Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. Dis Colon Rectum. 2007; 50:315–22.

6. Turaga KK, Pappas SG, Gamblin T. Importance of histologic sub-type in the staging of appendiceal tumors. Ann Surg Oncol. 2012; 19:1379–85.

7. van Eeden S, Offerhaus GJ, Hart AA, et al. Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology. 2007; 51:763–73.

8. Abrego D, Ibrahim AA. Mesenteric supernumerary ovary. Obstet Gynecol. 1975; 45:352–3.

9. Kearney MS. Synchronous benign teratomas of the greater omentum and ovary: case report. Br J Obstet Gynaecol. 1983; 90:676–9.

10. Lee KR, Young RH. The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases. Am J Surg Pathol. 2003; 27:281–92.