J Neurogastroenterol Motil.  2016 Jan;22(1):86-93. 10.5056/jnm15124.

Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis

Affiliations
  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. plrhee@skku.edu
  • 2Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
  • 3Department of Internal Medicine, Gangneung Asan Hospital, Ulsan University College of Medicine, Gangneung, Korea.
  • 4Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 5Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.
  • 6Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 7Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea.
  • 8Department of Internal Medicine, Kwangju Christian Hospital, Gwangju, Korea.

Abstract

BACKGROUND/AIMS
Limited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population.
METHODS
This was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out.
RESULTS
CR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence.
CONCLUSIONS
We should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.

Keyword

Gastroesophageal reflux; Quality of life; Recurrence; Therapy

MeSH Terms

Asian Continental Ancestry Group
Esophagitis
Follow-Up Studies*
Gastroesophageal Reflux*
Heartburn
Humans
Multivariate Analysis
Prospective Studies*
Quality of Life*
Recurrence*
Risk Factors
Treatment Outcome
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