Clin Pediatr Hematol Oncol.  2017 Apr;24(1):21-36. 10.15264/cpho.2017.24.1.21.

Renal Tumors in Children

  • 1Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.


Pediatric renal tumors represent a diverse group, which include Wilms' tumor (WT), renal cell carcinoma (RCC), clear cell sarcoma of the kidney (CCSK), congenital mesoblastic nephroma, malignant rhabdoid tumor of the kidney (MRTK) and primitive neuroectodermal tumor. WT (85%) and RCC (8%) are the most prevalent types. WT predominates among the 1- to 10-year age group, but RCC exceeds WT in children over age 10 years. Pediatric renal tumors are genetically, histologically and clinically heterogeneous. The overall survival for children with localized WT is currently more than 90%, whereas poorer survival rates are observed for anaplastic WT, metastatic WT, metastatic CCSK, MRTK, metastatic RCC and relapsed WT. Therefore risk-stratified treatment is important to minimize treatment morbidity while preserving survival. This review focuses on distinct characteristics of each tumor type and optimal stratified treatment.


Pediatric renal tumor; Risk-stratified treatment; Wilms' tumor; Renal cell carcinoma; Malignant rhabdoid tumor of the kidney; Clear cell sarcoma of the kidney

MeSH Terms

Carcinoma, Renal Cell
Nephroma, Mesoblastic
Neuroectodermal Tumors, Primitive
Rhabdoid Tumor
Sarcoma, Clear Cell
Survival Rate
Wilms Tumor
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