Obstet Gynecol Sci.  2017 May;60(3):308-313. 10.5468/ogs.2017.60.3.308.

Hyperthermic intrathoracic chemotherapy with cisplatin for ovarian cancer with pleural metastasis

• Jun SY
• Seok YK
• Kato T
• Chun DS
• Lee YH
• Chong GO
• Lee YS
• Cho YL
• Hong DG

• KMID: 2378594
• DOI: http://doi.org/10.5468/ogs.2017.60.3.308

Abstract

Intrathoracic metastasis of ovarian cancer has poor prognosis regardless of treatment modality. Recent development of surgical techniques and the new concept of direct infusion of chemotherapeutic agents with hyperthermia could help with the treatment of disseminated diseases in ovarian cancer. Using video-assisted thoracoscopic surgery and intracavitary chemotherapy with hyperthermia, we tried hyperthermic intrathoracic chemotherapy for a case of stage IV high-grade serous ovarian cancer with pleural metastasis. There was no high-grade complication related to the procedure. The patient is alive without disease at 32 months after initial treatment.

Keyword

Drug therapy; Fever; Neoplasm metastasis; Ovarian neoplasms

MeSH Terms

Cisplatin*
Drug Therapy*
Fever
Humans
Neoplasm Metastasis*
Ovarian Neoplasms*
Prognosis
Thoracic Surgery, Video-Assisted
Cisplatin

Figure

• 

  Fig. 1 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) suggested ovarian cancer. 18F-FDG PET/CT showed an (A) 11-cm mass in the pelvic cavity with high attenuation and hypermetabolism (arrow) and (B) a 6-cm mass in the cul de sac (arrow). (C) Chest CT showed tiny fissural nodules (arrow) in the right side lung, which suggested intrathoracic metastasis.

• 

  Fig. 2 Video-assisted thoracoscopic surgery and hyperthermic intrathoracic chemotherapy. (A) Three thoracostomies for thoracoscopy and inflow and outflow catheters. (B) Exploration to measure tumor extent (arrow, metastatic lesion). (C) After electrofulguration and wedge resection (arrows, metastatic lesion). (D) Insertion of lower inflow and upper outflow catheters. (E) Infusion of chemotherapeutic agent (arrow, attached temperature sensor). (F) Right chest cavity filled with infusion

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