World J Mens Health.  2017 Apr;35(1):51-56. 10.5534/wjmh.2017.35.1.51.

Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio?

Affiliations
  • 1Department of Urology, BaÄŸcılar Training and Research Hospital, Istanbul, Turkey.
  • 2Department of Urology, Okmeydanı Training and Research Hospital, Istanbul, Turkey. drhlcanat@gmail.com

Abstract

PURPOSE
The aim of this study was to evaluate the relationship of seminal parameters with the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), which are inflammatory markers, in men with an abnormal semen analysis and men with normozoospermia.
MATERIALS AND METHODS
Fifty-seven men with abnormal semen analyses and 59 men with normozoospermia were included in this cross-sectional study. A complete blood count was recorded, and the NLR and PLR were calculated from the hematologic parameters.
RESULTS
The NLR was 1.84±0.78 in the normozoospermic group and 1.80±0.75 in the abnormal semen analysis group. The PLR was 95.32±35.47 in the normozoospermic group and 93.57±28.09 in the abnormal semen analysis group. No significant differences were found between the normozoospermic and the abnormal semen analysis group in the NLR (p=0.828) or the PLR (p=0.768). In addition, no seminal parameters were correlated with the NLR or the PLR (p>0.05).
CONCLUSIONS
We do not recommend using the NLR or the PLR as markers to screen for abnormal semen parameters or male infertility.

Keyword

Infertility; Lymphocytes; Neutrophils; Semen analysis

MeSH Terms

Blood Cell Count
Cross-Sectional Studies
Humans
Infertility
Infertility, Male
Lymphocytes
Male
Neutrophils
Semen
Semen Analysis

Cited by  1 articles

Male Inflammatory Parameters Are not Useful to Predict the Outcomes of Intracytoplasmic Sperm Injection: Results from a Cross-Sectional Study
Gianmartin Cito, Maria Elisabetta Coccia, Rita Picone, Andrea Cocci, Giorgio Ivan Russo, Tommaso Cai, Giulia Bencini, Rossella Fucci, Elisabetta Micelli, Luciana Criscuoli, Francesco Bertocci, Elena Borrani, Sergio Serni, Marco Carini, Alessandro Natali
World J Mens Health. 2019;37(3):347-354.    doi: 10.5534/wjmh.180110.


Reference

1. Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod. 2010; 25:1383–1397. PMID: 20378615.
Article
2. Fraczek M, Kurpisz M. Cytokines in the male reproductive tract and their role in infertility disorders. J Reprod Immunol. 2015; 108:98–104. PMID: 25796532.
Article
3. Hamada A, Esteves SC, Nizza M, Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol. 2012; 38:576–594. PMID: 23131516.
Article
4. Zahorec R. Ratio of neutrophil to lymphocyte counts: rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001; 102:5–14. PMID: 11723675.
5. Celikbilek M, Dogan S, Ozbakır O, Zararsız G, Kücük H, Gürsoy S, et al. Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal. 2013; 27:72–76. PMID: 23292894.
Article
6. Kurtul BE, Ozer PA. The relationship between neutrophil-to-lymphocyte ratio and age-related macular degeneration. Korean J Ophthalmol. 2016; 30:377–381. PMID: 27729758.
Article
7. Duksal F, Alaygut D, Güven AS, Ekici M, Oflaz MB, Tuncer R, et al. Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article. Eur J Rheumatol. 2015; 2:20–23. PMID: 27708915.
Article
8. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012; 5:2. PMID: 22281066.
Article
9. World Health Organization (WHO). WHO Laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WHO Department of Reproductive Health and Research;2010.
10. Politch JA, Tucker L, Bowman FP, Anderson DJ. Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men. Hum Reprod. 2007; 22:2928–2935. PMID: 17855405.
Article
11. Lampiao F, du Plessis SS. TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online. 2008; 17:628–631. PMID: 18983746.
12. Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014; 4:4260. PMID: 24584780.
Article
13. Zalata A, Atwa A, El-Naser Badawy A, Aziz A, El-Baz R, Elhanbly S, et al. Tumor necrosis factor-α gene polymorphism relationship to seminal variables in infertile men. Urology. 2013; 81:962–966. PMID: 23465534.
Article
14. Hermosilla C, Caro TM, Silva LM, Ruiz A, Taubert A. The intriguing host innate immune response: novel anti-parasitic defence by neutrophil extracellular traps. Parasitology. 2014; 141:1489–1498. PMID: 24721985.
Article
15. Hales DB. Testicular macrophage modulation of Leydig cell steroidogenesis. J Reprod Immunol. 2002; 57:3–18. PMID: 12385830.
Article
16. Yoon NB, Son C, Um SJ. Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med. 2013; 33:105–110. PMID: 23482854.
Article
17. Wang GY, Yang Y, Li H, Zhang J, Jiang N, Li MR, et al. A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One. 2011; 6:e25295. PMID: 21966488.
Article
18. Kaya H, Ertaş F, İslamoğlu Y, Kaya Z, Atılgan ZA, Çil H, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost. 2014; 20:50–54. PMID: 22790659.
Article
19. Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 2014; 36:217–221. PMID: 23786430.
Article
20. Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP. Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol. 2013; 107:493–497. PMID: 22996403.
Article
21. Yao Y, Yuan D, Liu H, Gu X, Song Y. Pretreatment neutrophil to lymphocyte ratio is associated with response to therapy and prognosis of advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy. Cancer Immunol Immunother. 2013; 62:471–479. PMID: 22986452.
Article
22. Feng JF, Huang Y, Zhao Q, Chen QX. Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus. ScientificWorldJournal. 2013; DOI: 10.1155/2013/504365.
Article
23. Miglani RK, Bhateja N, Bhat RS, Kumar KV. Diagnostic role of platelet lymphocyte ratio (PLR) in pancreatic head masses. Indian J Surg. 2013; 75:4–9. PMID: 24426375.
24. Lewis SE. Is sperm evaluation useful in predicting human fertility? Reproduction. 2007; 134:31–40. PMID: 17641086.
Article
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