Osteoporos Sarcopenia.  2017 Mar;3(1):8-17. 10.1016/j.afos.2017.01.002.

Denosumab for the treatment of osteoporosis

• McClung MR

• KMID: 2376998
• DOI: http://doi.org/10.1016/j.afos.2017.01.002

Abstract

Denosumab, a specific inhibitor of RANK ligand, is a novel therapy for postmenopausal osteoporosis and related disorders. An extensive clinical development program has evaluated the clinical efficacy and safety of denosumab with several thousand patients being followed for up to 10 years. Combined with more than six years of postmarketing experience, these studies provide substantial confidence that denosumab is a convenient and appropriate treatment for patients, including Asians, at high risk for fracture. This review will summarize the clinical development of denosumab and lessons learned since its approval for clinical use in 2010.

Keyword

Denosumab; RANK ligand; Osteoporosis; Fracture; Drug safety

MeSH Terms

Asian Continental Ancestry Group
Denosumab*
Female
Humans
Osteoporosis*
Osteoporosis, Postmenopausal
RANK Ligand
Treatment Outcome
Denosumab
RANK Ligand