Int Neurourol J.  2017 Mar;21(1):62-67. 10.5213/inj.1732652.326.

Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study

• Solmaz V
• Albayrak S
• Tekatas A
• Aksoy D
• Gençten Y
• Ä°nanır S
• Erdemir F

• KMID: 2375595
• DOI: http://doi.org/10.5213/inj.1732652.326

Abstract

PURPOSE
In this study, we investigated overactive bladder (OAB) functions in male patients who used antidepressant drugs (ADs) that were previously examined in female patients, based on conflicting data in literature regarding the effects of AD on OAB and the differences between male and female urinary system physiologies (anatomical and hormonal).
METHODS
The study included 202 male patients (a control group of 90 healthy subjects, and an experimental group of 112 patients taking ADs for different disorders). All the patients completed the overactive bladder-validated 8 (OAB-V8) questionnaire, the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), and the Beck Depression Inventory (BDS).
RESULTS
The OAB-V8, ICIQ-SF, and BDS scores for the antidepressant users were significantly higher than those of the control group. The highest prevalence of OAB symptoms was observed in patients taking venlafaxine (68.2%), and the lowest prevalence was in patients taking sertraline (28.0%). Moreover, the frequency of OAB between the antidepressant groups was statistically significant. The univariate logistic regression analyses showed a significant relationship between the presence of OAB, antidepressant usage, BDS score, and the age of a patient. In the multivariate logistic regression analyses, the association between the presence of OAB and antidepressant usage was statistically significant.
CONCLUSIONS
The present study showed that the incidence of OAB and the severity of OAB symptoms increased in males using antidepressants for various disorders. This may have been due to unique pharmacological effects, on a molecular or individual level, of serotonin-norepinephrine reuptake inhibitors.

Keyword

Urinary Bladder, Overactive; Antidepressive Agents; Validation Studies

MeSH Terms

Antidepressive Agents
Depression
Female
Healthy Volunteers
Humans
Incidence
Logistic Models
Male*
Prevalence
Prospective Studies*
Sertraline
Urinary Bladder, Overactive*
Venlafaxine Hydrochloride
Antidepressive Agents
Sertraline
Venlafaxine Hydrochloride