Korean J Endocr Surg.  2011 Mar;11(1):18-21. 10.0000/kjes.2011.11.1.18.

Analysis of Clinicopathologic Factors Associated with Bilateral Thyroid Micro Papillary Carcinoma

• Kim KM
• Park JB
• Bae KS
• Kang SJ

• KMID: 2375364
• DOI: http://doi.org/10.0000/kjes.2011.11.1.18

Abstract

PURPOSE
Papillary thyroid carcinoma is the most common malignant tumor originating from the thyroid. The recent increase in frequency of thyroid ultrasonography is increasing the diagnostic rate of thyroid cancer, especially of the small-sized cancer. The appropriate extent of surgery for thyroid micropapillary carcinoma is still under debate, and bilaterality of the tumor may be an important factor determining the extent. Therefore, this study analyzed the clinicopathologic factors related to tumor bilaterality in order to help decide the extent of treatment.
METHODS
Subjects included 134 patients who received total thyroidectomy and central neck lymph node dissection at Wonju Christian Hospital under the diagnosis of thyroid micropapillary cancer from January 1(st), 1994 to December 31(st), 2009. The frequency of bilateral tumor among the subjects were studied, and the relationship between bilaterality and clinicopathologic factors, including patients' gender, age, tumor size, multiple mass in single lobe, capsule invasion, extrathyroidal extension, lymphovascular space invasion, central neck node invasion and lateral neck node invasion was analyzed.
RESULTS
There were 32 cases (23.9%) of bilateral tumor. Statistically significant factors related to bilaterality included two or more mass in a single lobe, perithyroidal soft tissue invasion.
CONCLUSION
When we plan thyroidectomy for thyroid micropapillary cancer, one cannot rule out the possibility of bilateral thyroid micropapillary cancer in patients with clinicopathologic factors related to bilaterality. Closer preoperative examination is thought to be required for such patients.

Keyword

Thyroid micropapillary carcinoma; Bilaterality; Multifocality

MeSH Terms

Carcinoma, Papillary*
Diagnosis
Gangwon-do
Humans
Lymph Node Excision
Neck
Thyroid Gland*
Thyroid Neoplasms
Thyroidectomy
Ultrasonography

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