Korean J Pediatr.  2017 Mar;60(3):55-63. 10.3345/kjp.2017.60.3.55.

Genetics of hereditary nephrotic syndrome: a clinical review

• Ha TS

• KMID: 2375167
• DOI: http://doi.org/10.3345/kjp.2017.60.3.55

Abstract

Advances in podocytology and genetic techniques have expanded our understanding of the pathogenesis of hereditary steroid-resistant nephrotic syndrome (SRNS). In the past 20 years, over 45 genetic mutations have been identified in patients with hereditary SRNS. Genetic mutations on structural and functional molecules in podocytes can lead to serious injury in the podocytes themselves and in adjacent structures, causing sclerotic lesions such as focal segmental glomerulosclerosis or diffuse mesangial sclerosis. This paper provides an update on the current knowledge of podocyte genes involved in the development of hereditary nephrotic syndrome and, thereby, reviews genotype-phenotype correlations to propose an approach for appropriate mutational screening based on clinical aspects.

Keyword

Nephrotic syndrome; Genetics; Inheritance

MeSH Terms

Genetic Association Studies
Genetic Techniques
Genetics*
Glomerulosclerosis, Focal Segmental
Humans
Mass Screening
Nephrotic Syndrome*
Podocytes
Sclerosis
Wills