Yonsei Med J.  2016 May;57(3):795-798. 10.3349/ymj.2016.57.3.795.

Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity

• Song YS
• Won JK
• Kim MJ
• Lee JH
• Kim DW
• Chung JK
• Park DJ
• Park YJ

• KMID: 2374104
• DOI: http://doi.org/10.3349/ymj.2016.57.3.795

Abstract

Thymic hyperplasia is frequently observed in Graves' disease. However, detectable massive enlargement of the thymus is rare, and the mechanism of its formation has remained elusive. This case showed dynamic changes in thymic hyperplasia on serial computed tomography images consistent with changes in serum thyrotropin receptor (TSH-R) antibodies and thyroid hormone levels. Furthermore, the patient's thymic tissues underwent immunohistochemical staining for TSH-R, which demonstrated the presence of thymic TSH-R. The correlation between serum TSH-R antibody levels and thymic hyperplasia sizes and the presence of TSH-R in her thymus suggest that TSH-R antibodies could have a pathogenic role in thymic hyperplasia.

Keyword

Thymus hyperplasia; graves disease; receptors thyrotropin; immunoglobulins, thyroid-stimulating

MeSH Terms

Adult
Female
Graves Disease/*complications/surgery/therapy
Humans
Male
Receptors, Thyrotropin/blood
Thymus Gland/diagnostic imaging
Thymus Hyperplasia/*diagnostic imaging/etiology/immunology
Thyroid Hormones
Thyroidectomy
Thyrotropin/blood
Tomography, X-Ray Computed
Young Adult
Receptors, Thyrotropin
Thyroid Hormones
Thyrotropin