J Korean Med Sci.  2016 May;31(5):801-805. 10.3346/jkms.2016.31.5.801.

Trends of Incidence, Mortality, and Future Projection of Spinal Fractures in Korea Using Nationwide Claims Data

Affiliations
  • 1Department of Orthopaedic Surgery, School of Medicine, Hallym University, Anyang, Korea.
  • 2College of Pharmacy, Gachon University, Incheon, Korea.
  • 3Division for Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.
  • 4Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 5Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea.
  • 6Big Data Steering Department, National Health Insurance Service, Seoul, Korea.
  • 7Department of Orthopaedic Surgery, College of Medicine, Chung-Ang University, Seoul, Korea. hayongch@naver.com

Abstract

Spinal fractures have been recognized as a major health concern. Our purposes were to evaluate the trends in the incidence and mortality of spinal fractures between 2008 and 2012 and predict the number of spinal fractures that will occur in Korea up to 2025, using nationwide data from the National Health Insurance Service (NHIS). A nationwide data set was evaluated to identify all new visits to medical institutes for spinal fractures in men and women aged 50 years or older between 2008 and 2012. The incidence, mortality rates and estimates of the number of spinal fractures were calculated using Poisson regression. The number of spinal fractures increased over the time span studied. Men and women experienced 14,808 and 55,164 vertebral fractures in 2008 and 22,739 and 79,903 in 2012, respectively. This reflects an increase in the incidence of spinal fractures for both genders (men, 245.3/100,000 in 2008 and 312.5/100,000 in 2012; women, 780.6/100,000 in 2008 and 953.4/100,000 in 2012). The cumulative mortality rate in the first year after spinal fractures decreased from 8.51% (5,955/69,972) in 2008 to 7.0% (7,187/102,642) in 2012. The overall standardized mortality ratio (SMR) of spinal fractures at 1 year post-fracture was higher in men (7.76, 95% CI: 7.63-7.89) than in women (4.70, 95% CI: 4.63-4.76). The total number of spinal fractures is expected to reach 157,706 in 2025. The incidence of spinal fractures increased in Korea in the last 5 years, and the socioeconomic burden of spinal fractures will continue to increase in the near future.

Keyword

Spinal Fracture; Mortality; Projection; Osteoporosis, Korea

MeSH Terms

Aged
Aged, 80 and over
Databases, Factual
Female
Humans
Incidence
Insurance Claim Review
Male
Middle Aged
Republic of Korea
Retrospective Studies
Spinal Fractures/*epidemiology/mortality
Survival Rate

Figure

  • Fig. 1 Age-specific incidence of spinal fractures in Koreans aged 50 years and older from 2008 to 2012.

  • Fig. 2 Estimated number of spinal fractures in Korea up to the year 2025.


Cited by  8 articles

Hip and Subtrochanteric or Femoral Shaft Fractures after Bisphosphonate Use in Korean Women, Using Korean National Sample Cohort
Seok-Hyung Won, Soyeon Ahn, Eunjeong Ji, Jung Wee Park, Jin-Kak Kim, Young-Kyun Lee
J Korean Med Sci. 2020;35(25):e193.    doi: 10.3346/jkms.2020.35.e193.

Utilization of Osteoporosis-Related Health Services: Use of Data from the Korean National Health Insurance Database 2008–2012
Tae Yang Yu, Hyemin Cho, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
J Korean Med Sci. 2018;33(3):.    doi: 10.3346/jkms.2018.33.e20.

Epidemiology of osteoporosis in Korea
Yong-Chan Ha
J Korean Med Assoc. 2016;59(11):836-841.    doi: 10.5124/jkma.2016.59.11.836.

Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011
Ha Young Kim, Yong-Chan Ha, Tae-Young Kim, Hyemin Cho, Young-Kyun Lee, Ji-Yeon Baek, Sunmee Jang
J Bone Metab. 2017;24(2):125-133.    doi: 10.11005/jbm.2017.24.2.125.

Incidence and Mortality of Osteoporotic Fracture in Rheumatoid Arthritis in South Korea Using Nationwide Claims Data
Hye-Young Kwon, Hyun-Ho Kim, Yoon-Kyoung Sung, Yong-Chan Ha
J Bone Metab. 2019;26(2):97-104.    doi: 10.11005/jbm.2019.26.2.97.

Incidence Rate of Atypical Femoral Fracture after Bisphosphonates Treatment in Korea
Young-Kyun Lee, Soyeon Ahn, Kyoung Min Kim, Chang Suk Suh, Kyung-Hoi Koo
J Korean Med Sci. 2018;33(5):.    doi: 10.3346/jkms.2018.33.e38.

Operational Definition Identifying Osteoporotic Vertebral Fractures in the Claims Database
Min Heui Yu, Namki Hong, Seunghyun Lee, Ha-Young Kim, Hye-Sun Park, Sang-Min Park, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Yumie Rhee, Kyung-Hoi Koo
J Korean Med Sci. 2022;37(32):e249.    doi: 10.3346/jkms.2022.37.e249.

The Impact of Persistent Low Weight Status on the Occurrence of Vertebral Fractures: A Nationwide Population-Based Cohort Study
Sang-Min Park, Jiwon Park, Sangsoo Han, Hae-Dong Jang, Jae-Young Hong, Kyungdo Han, Ho-Joong Kim, Jin S. Yeom
J Korean Med Sci. 2023;38(7):e48.    doi: 10.3346/jkms.2023.38.e48.


Reference

1. Cheung G, Chow E, Holden L, Vidmar M, Danjoux C, Yee AJ, Connolly R, Finkelstein J. Percutaneous vertebroplasty in patients with intractable pain from osteoporotic or metastatic fractures: a prospective study using quality-of-life assessment. Can Assoc Radiol J. 2006; 57:13–21.
2. Salaffi F, Cimmino MA, Malavolta N, Carotti M, Di Matteo L, Scendoni P, Grassi W; Italian Multicentre Osteoporotic Fracture Study Group. The burden of prevalent fractures on health-related quality of life in postmenopausal women with osteoporosis: the IMOF study. J Rheumatol. 2007; 34:1551–1560.
3. Lee YK, Jang S, Jang S, Lee HJ, Park C, Ha YC, Kim DY. Mortality after vertebral fracture in Korea: analysis of the National Claim Registry. Osteoporos Int. 2012; 23:1859–1865.
4. Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton LJ 3rd. Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993; 137:1001–1005.
5. Ensrud KE, Thompson DE, Cauley JA, Nevitt MC, Kado DM, Hochberg MC, Santora AC 2nd, Black DM; Fracture Intervention Trial Research Group. Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. J Am Geriatr Soc. 2000; 48:241–249.
6. Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999; 353:878–882.
7. Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O; European Vertebral Osteoporosis Study. Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study. Osteoporos Int. 2003; 14:61–68.
8. Lau E, Ong K, Kurtz S, Schmier J, Edidin A. Mortality following the diagnosis of a vertebral compression fracture in the Medicare population. J Bone Joint Surg Am. 2008; 90:1479–1486.
9. Bouza C, López T, Palma M, Amate JM. Hospitalised osteoporotic vertebral fractures in Spain: analysis of the national hospital discharge registry. Osteoporos Int. 2007; 18:649–657.
10. Chen IJ, Chiang CY, Li YH, Chang CH, Hu CC, Chen DW, Chang Y, Yang WE, Shih HN, Ueng SW, et al. Nationwide cohort study of hip fractures: time trends in the incidence rates and projections up to 2035. Osteoporos Int. 2015; 26:681–688.
11. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007; 22:465–475.
12. Sung SK, Lee SG, Lee KS, Kim DS, Kim KH, Kim KY. First-year treatment adherence among outpatients initiating antihypertensive medication in Korea: results of a retrospective claims review. Clin Ther. 2009; 31:1309–1320.
13. Lee YK, Ha YC, Park C, Yoo JJ, Shin CS, Koo KH. Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea: results from the National Claim Registry. Osteoporos Int. 2013; 24:707–711.
14. Lee YK, Yoon BH, Nho JH, Kim KC, Ha YC, Koo KH. National trends of surgical treatment for intertrochanteric fractures in Korea. J Korean Med Sci. 2013; 28:1407–1408.
15. Kim SH, Ko YB, Lee YK, Hong SW, Choi HJ, Ha YC, Shin CS. National utilization of calcium supplements in patients with osteoporotic hip fracture in Korea. J Bone Metab. 2013; 20:99–103.
16. Statistics Korea. Korean Statistical Information Service. accessed on 9 September 2015. Available at http://www.kosis.kr/.
17. Koski AM, Patala A, Patala E, Sund R. Incidence of osteoporotic fractures in elderly women and men in Finland during 2005-2006: a population-based study. Scand J Surg. 2014; 103:215–221.
18. Sakuma M, Endo N, Oinuma T, Endo E, Yazawa T, Watanabe K, Watanabe S. Incidence and outcome of osteoporotic fractures in 2004 in Sado City, Niigata Prefecture, Japan. J Bone Miner Metab. 2008; 26:373–378.
19. Bow CH, Cheung E, Cheung CL, Xiao SM, Loong C, Soong C, Tan KC, Luckey MM, Cauley JA, Fujiwara S, et al. Ethnic difference of clinical vertebral fracture risk. Osteoporos Int. 2012; 23:879–885.
20. Siggeirsdottir K, Aspelund T, Jonsson BY, Mogensen B, Gudmundsson EF, Gudnason V, Sigurdsson G. Epidemiology of fractures in Iceland and secular trends in major osteoporotic fractures 1989-2008. Osteoporos Int. 2014; 25:211–219.
21. Wang H, Li C, Xiang Q, Xiong H, Zhou Y. Epidemiology of spinal fractures among the elderly in Chongqing, China. Injury. 2012; 43:2109–2116.
22. Oinuma T, Sakuma M, Endo N. Secular change of the incidence of four fracture types associated with senile osteoporosis in Sado, Japan: the results of a 3-year survey. J Bone Miner Metab. 2010; 28:55–59.
23. Cooper C, Atkinson EJ, Kotowicz M, O’Fallon WM, Melton LJ 3rd. Secular trends in the incidence of postmenopausal vertebral fractures. Calcif Tissue Int. 1992; 51:100–104.
24. Gauthier A, Kanis JA, Jiang Y, Martin M, Compston JE, Borgström F, Cooper C, McCloskey EV. Epidemiological burden of postmenopausal osteoporosis in the UK from 2010 to 2021: estimations from a disease model. Arch Osteoporos. 2011; 6:179–188.
25. Cawston H, Maravic M, Fardellone P, Gauthier A, Kanis JA, Compston J, Borgström F, Cooper C, McCloskey E. Epidemiological burden of postmenopausal osteoporosis in France from 2010 to 2020: estimations from a disease model. Arch Osteoporos. 2012; 7:237–246.
26. Piscitelli P, Brandi M, Cawston H, Gauthier A, Kanis JA, Compston J, Borgström F, Cooper C, McCloskey E. Epidemiological burden of postmenopausal osteoporosis in Italy from 2010 to 2020: estimations from a disease model. Calcif Tissue Int. 2014; 95:419–427.
27. Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B. Excess mortality after hospitalisation for vertebral fracture. Osteoporos Int. 2004; 15:108–112.
28. Cauley JA, Thompson DE, Ensrud KC, Scott JC, Black D. Risk of mortality following clinical fractures. Osteoporos Int. 2000; 11:556–561.
29. Ioannidis G, Papaioannou A, Hopman WM, Akhtar-Danesh N, Anastassiades T, Pickard L, Kennedy CC, Prior JC, Olszynski WP, Davison KS, et al. Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. CMAJ. 2009; 181:265–271.
30. Teng GG, Curtis JR, Saag KG. Mortality and osteoporotic fractures: is the link causal, and is it modifiable? Clin Exp Rheumatol. 2008; 26:S125–37.
31. Papaioannou A, Adachi JD, Parkinson W, Stephenson G, Bédard M. Lengthy hospitalization associated with vertebral fractures despite control for comorbid conditions. Osteoporos Int. 2001; 12:870–874.
32. Ismail AA, O’Neill TW, Cooper C, Finn JD, Bhalla AK, Cannata JB, Delmas P, Falch JA, Felsch B, Hoszowski K, et al. Mortality associated with vertebral deformity in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int. 1998; 8:291–297.
33. Si L, Winzenberg TM, Jiang Q, Chen M, Palmer AJ. Projection of osteoporosis-related fractures and costs in China: 2010-2050. Osteoporos Int. 2015; 26:1929–1937.
34. Shao CJ, Hsieh YH, Tsai CH, Lai KA. A nationwide seven-year trend of hip fractures in the elderly population of Taiwan. Bone. 2009; 44:125–129.
35. Tsukutani Y, Hagino H, Ito Y, Nagashima H. Epidemiology of fragility fractures in Sakaiminato, Japan: incidence, secular trends, and prognosis. Osteoporos Int. 2015; 26:2249–2255.
36. Park C, Ha YC, Jang S, Jang S, Yoon HK, Lee YK. The incidence and residual lifetime risk of osteoporosis-related fractures in Korea. J Bone Miner Metab. 2011; 29:744–751.
Full Text Links
  • JKMS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr