Clin Mol Hepatol.  2016 Sep;22(3):396-399. 10.3350/cmh.2015.0039.

A Korean patient with Guillain-Barré syndrome following acute hepatitis E whose cholestasis resolved with steroid therapy

• Ji SB
• Lee SS
• Jung HC
• Kim HJ
• Kim HJ
• Kim TH
• Jung WT
• Lee OJ
• Song DH

• KMID: 2373141
• DOI: http://doi.org/10.3350/cmh.2015.0039

Abstract

Autochthonous hepatitis E virus (HEV) is an emerging pathogen in developed countries, and several cases of acute HEV infection have been reported in South Korea. However, there have been no reports on HEV-associated Guillain-Barré syndrome (GBS) in Korea. We recently experienced the case of a 58-year-old Korean male with acute HEV infection after ingesting raw deer meat. Persistent cholestasis was resolved by the administration of prednisolone. At 2.5 months after the clinical presentation of HEV infection, the patient developed weakness of the lower limbs, and was diagnosed with GBS associated with acute hepatitis E. To our knowledge, this is the second report on supportive steroid therapy for persistent cholestasis due to hepatitis E, and the first report of GBS in a Korean patient with acute HEV infection.

Keyword

Hepatitis E; Jaundice; Steroid treatment; Guillain-Barré syndrome

MeSH Terms

Acute Disease
Alanine Transaminase/blood
Antibodies, Viral/blood
Aspartate Aminotransferases/blood
Bilirubin/analysis
Cholestasis/*drug therapy
Guillain-Barre Syndrome/complications/*diagnosis
Hepatitis E/*diagnosis/etiology
Hepatitis E virus/immunology
Humans
Immunoglobulin M/blood
Liver/pathology
Male
Middle Aged
Prednisolone/therapeutic use
Republic of Korea
Steroids/*therapeutic use
Alanine Transaminase
Antibodies, Viral
Aspartate Aminotransferases
Bilirubin
Immunoglobulin M
Prednisolone
Steroids