Obstet Gynecol Sci.  2017 Mar;60(2):227-231. 10.5468/ogs.2017.60.2.227.

Mucinous cystadenocarcinoma of ovary with metastasis in 14-year-old girl

• Gupta B
• Arora P
• Khurana N
• Tempe A

• KMID: 2372810
• DOI: http://doi.org/10.5468/ogs.2017.60.2.227

Abstract

Ovarian mucinous tumors in <15 years old are rare with <50 cases reported till date in the literature. Majority of them are benign or borderline epithelial ovarian tumors with only 12 cases of cystadenocarcinomas reported at a young age. We report a case of mucinous cystadenocarcinoma in 14-year-old girl with metastasis to omentum at the time of presentation. Management of such cases is tricky as conservative approach sparing fertility of the patient is adopted. This case is presented for its rarity and unique presentation. To the best of our knowledge, this is the thirteenth case of ovarian cystadenocarcinoma being reported at a very young age and the first case being reported from Indian subcontinent. Extensive review of the previously published cases in the literature has been done in this study.

Keyword

Cystadenocarcinoma; Mucinous; Neoplasm metastasis; Omentum; Ovary

MeSH Terms

Adolescent*
Cystadenocarcinoma
Cystadenocarcinoma, Mucinous*
Female
Female*
Fertility
Humans
Mucins*
Neoplasm Metastasis*
Omentum
Ovary*
Mucins

Figure

• 

  Fig. 1 (A) Gross: ovarian cyst. Cut section is solid cystic with multi-loculated cysts filled with mucinous material. (B) Microscopy: back to back arrangement of glands lined by mucin secreting epithelium infiltrating the stroma (H&E, ×200).

Reference

1. Horiuchi A, Kameoka K, Sato K, Yamamoto Y, Watanabe Y. Huge mucinous borderline ovarian cystadenoma in a premenarchal girl. Open J Pediatrics. 2012; 2:82–86.

2. Hong SJ, Lurain JR, Tsukada Y, Piver MS, Humbert JR, Freeman AI. Cystadenocarcinoma of the ovary in a 4-year-old: benign transformation during therapy. Cancer. 1980; 45:2227–2230. PMID: 7370965.

3. Blom GP, Torkildsen EM. Ovarian cystadenocarcinoma in a 4-year-old girl: report of a case and review of the literature. Gynecol Oncol. 1982; 13:242–246. PMID: 7076039.

4. Gribbon M, Ein SH, Mancer K. Pediatric malignant ovarian tumors: a 43-year review. J Pediatr Surg. 1992; 27:480–484. PMID: 1326038.

5. Skinner MA, Schlatter MG, Heifetz SA, Grosfeld JL. Ovarian neoplasms in children. Arch Surg. 1993; 128:849–853. PMID: 8343057.

6. Deprest J, Moerman P, Corneillie P, Ide P. Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. Gynecol Oncol. 1992; 45:219–224. PMID: 1592292.

7. Shankar KR, Wakhlu A, Kokai GK, McDowell H, Jones MO. Ovarian adenocarcinoma in premenarchal girls. J Pediatr Surg. 2001; 36:511–515. PMID: 11227010.

8. Iwasaki M, Taira K, Kobayashi H, Saiga T. Ovarian mucinous cystadenoma of borderline malignancy in a premenarchal girl. J Pediatr Adolesc Gynecol. 2010; 23:e119–e123. PMID: 19896401.

9. Hernandez E, Rosenshein NB, Parmley TH. Mucinous cystadenocarcinoma in a premenarchal girl. South Med J. 1982; 75:1265–1267. PMID: 7123301.

10. Morowitz M, Huff D, von Allmen D. Epithelial ovarian tumors in children: a retrospective analysis. J Pediatr Surg. 2003; 38:331–335. PMID: 12632344.

11. Zanaboni F, Vergadoro F, Presti M, Gallotti P, Lombardi F, Bolis G. Tumor antigen CA 125 as a marker of ovarian epithelial carcinoma. Gynecol Oncol. 1987; 28:61–67. PMID: 2443433.

12. Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Surgical management of borderline ovarian tumors: the role of fertility-sparing surgery. Gynecol Oncol. 2009; 113:75–82. PMID: 19171373.

13. Aggarwal A, Lucco KL, Lacy J, Kives S, Gerstle JT, Allen L. Ovarian epithelial tumors of low malignant potential: a case series of 5 adolescent patients. J Pediatr Surg. 2009; 44:2023–2027. PMID: 19853767.

14. ICON Collaborators. International Collaborative Ovarian Neoplasm Study. ICON2: randomised trial of single-agent carboplatin against three-drug combination of CAP (cyclophosphamide, doxorubicin, and cisplatin) in women with ovarian cancer. Lancet. 1998; 352:1571–1576. PMID: 9843101.

15. Brower MS, Coleman M, Pasmantier MW, Silver RT, Mamaril AP, Quiguyan CC. Treatment of advanced ovarian carcinoma with hexamethylmelamine, doxorubicin, and cis-platinum (HAC): results in both untreated and previously treated patients. Med Pediatr Oncol. 1984; 12:17–24. PMID: 6321930.