Neonatal Med.  2017 Feb;24(1):7-12. 10.5385/nm.2017.24.1.7.

Impact of Postnatal Acidosis on Short Term Outcomes in Very Low Birth Weight Infants

• Kim M
• Kim SK
• Kim GJ
• Lee JH

• KMID: 2371409
• DOI: http://doi.org/10.5385/nm.2017.24.1.7

Abstract

PURPOSE
This study aimed to evaluate the effects of postnatal acidosis on the short-term clinical outcomes or neonatal mortality in very low birth weight (VLBW) infants.
METHODS
We retrospectively reviewed the data of 157 VLBW infants. The study population was divided into three categories: two acidosis groups and one control group, based on blood pH, base excess, and partial pressure of carbon dioxide. The primary outcome variables were massive pulmonary hemorrhage (MPH), apnea, and early death. The secondary outcomes were intraventricular hemorrhage (grade III-IV), necrotizing enterocolitis, bronchopulmonary dysplasia, retinopathy of prematurity, and death before 36 weeks' postmenstrual age.
RESULTS
After adjustment for birth weight, gestational age and Apgar score, compared to the control group (n=97), MPH and early death were more common in acidosis 1 (n=21) and acidosis 2 (n=39) groups, respectively. There were no differences between the acidosis groups and the control group with respect to other important neonatal outcomes.
CONCLUSION
Postnatal acidosis was related to an increased risk of MPH and early neonatal mortality in VLBW infants.

Keyword

Acidosis; Low birth weight infant; Prognosis

MeSH Terms

Acidosis*
Apgar Score
Apnea
Birth Weight
Bronchopulmonary Dysplasia
Carbon Dioxide
Enterocolitis, Necrotizing
Gestational Age
Hemorrhage
Humans
Hydrogen-Ion Concentration
Infant Mortality
Infant*
Infant, Low Birth Weight
Infant, Newborn
Infant, Very Low Birth Weight*
Partial Pressure
Prognosis
Retinopathy of Prematurity
Retrospective Studies
Carbon Dioxide