Ann Lab Med.  2017 May;37(3):290-292. 10.3343/alm.2017.37.3.290.

Two Cases of Antibody-Mediated Rejection Following Kidney Transplantation due to HLA-DQB1 Allele-Specific and DQ Alpha Protein-Specific HLA Antibodies

Affiliations
  • 1Department of Transplantation Surgery, Severance Hospital, Yonsei University Healthcare System, Seoul, Korea.
  • 2Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea. borae.park@gmail.com
  • 3Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Antibodies*
Kidney Transplantation*
Kidney*
Antibodies

Reference

1. Willicombe M, Brookes P, Sergeant R, Santos-Nunez E, Steggar C, Galliford J, et al. De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy. Transplantation. 2012; 94:172–177. PMID: 22735711.
2. Carta P, Di Maria L, Caroti L, Buti E, Antognoli G, Minetti EE. Anti-human leukocyte antigen DQ antibodies in renal transplantation: Are we underestimating the most frequent donor specific alloantibodies? Transplant Rev (Orlando). 2015; 29:135–138. PMID: 25976621.
3. Tambur AR, Leventhal JR, Zitzner JR, Walsh RC, Friedewald JJ. The DQ barrier: improving organ allocation equity using HLA-DQ information. Transplantation. 2013; 95:635–640. PMID: 23288109.
4. Lomago J, Jelenik L, Zern D, Howe J, Martell J, Zeevi A, et al. How did a patient who types for HLA-B*4403 develop antibodies that react with HLA-B*4402? Hum Immunol. 2010; 71:176–178. PMID: 19963027.
5. Cecka JM, Reed EF, Zachary AA. HLA high-resolution typing for sensitized patients: a solution in search of a problem? Am J Transplant. 2015; 15:855–856. PMID: 25778678.
6. Baxter-Lowe LA, Cecka M, Kamoun M, Sinacore J, Melcher ML. Center-defined unacceptable HLA antigens facilitate transplants for sensitized patients in a multi-center kidney exchange program. Am J Transplant. 2014; 14:1592–1598. PMID: 24934640.
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