Korean J Clin Oncol.  2016 Dec;12(2):104-109. 10.14216/kjco.16017.

Outcomes after local excision for rectal neuroendocrine tumor

• Kwon Y
• Ryoo SB
• Song I
• Kwon YH
• Lee DW
• Moon SH
• Park JW
• Jeong SY
• Park KJ

• KMID: 2369133
• DOI: http://doi.org/10.14216/kjco.16017

Abstract

PURPOSE
Neuroendocrine tumor is a rare tumor in the rectum, but incidence has been increasing. Local excision is an option for treatment of small tumors, and transanal excision or endoscopic resection can be undergone. But indications for local excision have not been established yet. This study was to compare the long-term oncologic outcomes between transanal excision and endoscopic resection for rectal neuroendocrine tumor.
METHODS
Patients diagnosed and treated with rectal neuroendocrine tumor from 2000 to 2015 were collected prospectively, and medical records were analyzed retrospectively.
RESULTS
Forty patients were included, mean age was 50.20±13.35 years (male:female=23:17). Transanal excision and endoscopic resection were performed in 28 (70%) and 12 (30%) patients, respectively. Mean tumor size was 0.63±0.37 cm, and tumor location was 5.45±1.89 cm from anal verge. Tumor location was more distal rectum in transanal excision (5.04±1.73 cm vs. 6.42±1.98 cm, P=0.049). Pathologic T stage was T1 in all patients. Most of the patients (90%) showed tumor grade 1. After median 24 months (range, 0-86 months) follow-up, one patient (2.5%) experienced local recurrence. The patient underwent further transanal excision. There was no mortality after local excision.
CONCLUSION
Local excision is a safe and effective treatment for small-sized neuroendocrine tumors in rectum.

Keyword

Neuroendocrine tumor; Rectal neoplasm; Carcinoid tumor

MeSH Terms

Carcinoid Tumor
Follow-Up Studies
Humans
Incidence
Medical Records
Mortality
Neuroendocrine Tumors*
Prospective Studies
Rectal Neoplasms
Rectum
Recurrence
Retrospective Studies