Korean J Vet Res.  2016 Sep;56(3):139-145. 10.14405/kjvr.2016.56.3.139.

Prognostic factors and efficacy of human intravenous immunoglobulin G in dogs with idiopathic immune-mediated hemolytic anemia: a retrospective study

• Park SY
• Kim H
• Kang BT
• Kang JH
• Yang MP

• KMID: 2368759
• DOI: http://doi.org/10.14405/kjvr.2016.56.3.139

Abstract

This study was conducted to determine the effect of treatment with intravenous human immunoglobulin G (hIVIgG) on outcome in dogs with idiopathic immune-mediated hemolytic anemia (IMHA), and to identify prognostic variables that determine outcome in affected dogs. Thirty-seven dogs that met the inclusion criteria were enrolled in a retrospective study. The dogs were categorized into two groups based on their having received hIVIgG. There was no significant difference in survival between the hIVIgG group and the non-hIVIgG group. Mortality during hospitalization and at 1 month, 1 year, or 2 years after discharge was not significantly different between the hIVIgG and the non-hIVIgG groups. Hemoglobinuria was significantly less prevalent in dogs that lived more than 1 year than in those who lived less than 1 year, and was less prevalent in dogs that lived more than 2 years than in those who lived less than 2 years. However, there was no difference in the presence of hemoglobinuria between dogs that lived less than 1 month and those that lived more than 1 month. Overall, there was no evidence of a beneficial effect of hIVIgG in dogs with idiopathic IMHA.

Keyword

autoimmune hemolytic anemia; canine; hemoglobinuria; mortality; seasonality

MeSH Terms

Anemia, Hemolytic*
Anemia, Hemolytic, Autoimmune
Animals
Dogs*
Hemoglobinuria
Hospitalization
Humans*
Immunoglobulin G*
Immunoglobulins*
Mortality
Retrospective Studies*
Immunoglobulin G
Immunoglobulins