Chonnam Med J.  2017 Jan;53(1):78-80. 10.4068/cmj.2017.53.1.78.

Clinical Application of the Unifying Concept of Cutaneous Melanoma

• Roncati L
• Piscioli F
• Pusiol T

• KMID: 2367344
• DOI: http://doi.org/10.4068/cmj.2017.53.1.78

Abstract

No abstract available.

MeSH Terms

Melanoma*

Figure

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  FIG. 1 Schematic representation of the progression from normal skin to invasive malignant melanoma. (A) Normal skin with melanocytes (smaller grey bullets) regularly distributed at the basis of the epidermis (black line). (B) Epidermis with basal hyperplastic melanocytes. (C) Epidermis with basal atypical melanocytes (larger grey bullets). (D) Intra-epidermal radial growth phase of primary malignant melanoma with lentiginous pattern. (E) Intra-epidermal radial growth phase of primary malignant melanoma with pagetoid pattern. (F) Micro-invasive radial growth phase of primary malignant melanoma with lentiginous pattern (single melanoma cells are present in the papillary dermis). (G) Micro-invasive radial growth phase of primary malignant melanoma with pagetoid pattern (small clusters of melanoma cells are present in the papillary dermis). (H) Invasive (early if ≤1 mm in thick) vertical growth phase of primary cutaneous malignant melanoma (large clusters of melanoma cells are present in the papillary dermis and beyond).

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  FIG. 2 Histopathological exemplification of the radial growth phase (A: hematoxylin/eosin, 4×) and of the vertical one (B: hematoxylin/eosin, 4×) in primary cutaneous malignant melanoma.

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