Blood Res.  2016 Dec;51(4):293-296. 10.5045/br.2016.51.4.293.

Factors associated with vasovagal reactions in apheresis plasma and whole blood donors: a statistical-epidemiological study in a European donor cohort

• Seheult JN
• Lund ME
• Yazer MH
• Titlestad

• KMID: 2364325
• DOI: http://doi.org/10.5045/br.2016.51.4.293

Abstract

No abstract available.

MeSH Terms

Blood Component Removal*
Blood Donors*
Cohort Studies*
Humans
Plasma*
Tissue Donors*

Figure

• 

  Fig. 1 Vasovagal reaction (VVR) rate stratified by donation type, age group and gender. The average VVR rate was not different between males and females for whole blood donations (<=0.490), but there was a trend towards a higher rate of VVRs in male whole blood donors less than 30 years of age (43/5,030 for males vs. 40/6,233 for females, <=0.192) and female donors greater than 30 years of age (11/11,370 for males vs. 14/8,127 for females, <=0.147). Female apheresis plasma donors experienced a mean VVR rate that was twice as high compared to male plasma donors (P<0.001) and the trend towards higher VVR rates in females was consistent across all age groups.

• 

  Fig. 2 Number and rate of vasovagal reactions (VVRs) stratified by donation number. The solid bars represent the number of VVRs that occurred on each donation number. The dashed line represents the rate of VVRs expressed by donation number for all donors; for example, the rate of VVRs on the first donation recorded for all donors in the registry was 0.6% for whole blood and 2.1% for apheresis plasma donations. The majority of VVRs occurred during the first two donations in the whole blood group and during the first three donations in the apheresis plasma group. No VVR occurred after donation number five in the whole blood group, whereas 33 VVRs occurred during donation numbers six and twenty-one in the apheresis plasma group.

Reference

1. Wiersum-Osselton JC, Marijt-van der Kreek T, Brand A, Veldhuizen I, van der Bom JG, de Kort W. Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return. Blood Transfus. 2014; 12(Suppl 1):s28–s36. PMID: 23867173.

2. Sorensen BS, Johnsen SP, Jorgensen J. Complications related to blood donation: a population-based study. Vox Sang. 2008; 94:132–137. PMID: 18028259.

3. Burkhardt T, Dimanski B, Karl R, et al. Donor vigilance data of a blood transfusion service: A multicenter analysis. Transfus Apher Sci. 2015; 53:180–184. PMID: 26074050.

4. Newman B, Tommolino E, Andreozzi C, Joychan S, Pocedic J, Heringhausen J. The effect of a 473-mL (16-oz) water drink on vasovagal donor reaction rates in high-school students. Transfusion. 2007; 47:1524–1533. PMID: 17655598.

5. Crocco I, Franchini M, Garozzo G, et al. Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres. Blood Transfus. 2009; 7:35–38. PMID: 19290078.

6. Winters JL. Complications of donor apheresis. J Clin Apher. 2006; 21:132–141. PMID: 15880355.

7. Eder AF, Dy BA, Kennedy JM, et al. The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. Transfusion. 2008; 48:1809–1819. PMID: 18631167.

8. Eder AF, Hillyer CD, Dy BA, Notari EP 4th, Benjamin RJ. Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds. JAMA. 2008; 299:2279–2286. PMID: 18492969.

9. Wiltbank TB, Giordano GF, Kamel H, Tomasulo P, Custer B. Faint and prefaint reactions in whole-blood donors: an analysis of predonation measurements and their predictive value. Transfusion. 2008; 48:1799–1808. PMID: 18482188.

10. Rios JA, Fang J, Tu Y, et al. The potential impact of selective donor deferrals based on estimated blood volume on vasovagal reactions and donor deferral rates. Transfusion. 2010; 50:1265–1275. PMID: 20113451.

11. Bravo M, Kamel H, Custer B, Tomasulo P. Factors associated with fainting: before, during and after whole blood donation. Vox Sang. 2011; 101:303–312. PMID: 21535440.

12. Fisher SA, Allen D, Dorée C, Naylor J, Angelantonio ED, Roberts DJ. Interventions to reduce vasovagal reactions in blood donors: a systematic review and meta-analysis. Transfus Med. 2016; 26:15–33. PMID: 27061617.

13. Newman B, Siegfried B, Buchanan L. Are vasovagal reaction rates in blood donors related to the duration of the phlebotomy? Transfusion. 2008; 48:568–569. PMID: 18302666.

14. Ditto B, France CR. Vasovagal symptoms mediate the relationship between predonation anxiety and subsequent blood donation in female volunteers. Transfusion. 2006; 46:1006–1010. PMID: 16734818.

15. Takanashi M, Odajima T, Aota S, et al. Risk factor analysis of vasovagal reaction from blood donation. Transfus Apher Sci. 2012; 47:319–325. PMID: 22647682.