J Korean Assoc Oral Maxillofac Surg.  2015 Aug;41(4):181-189. 10.5125/jkaoms.2015.41.4.181.

Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation

• Faramarzi
• Goharfar Z
• Pourabbas
• Kashefimehr A
• Shirmohmmadi A

• KMID: 2364014
• DOI: http://doi.org/10.5125/jkaoms.2015.41.4.181

Abstract

OBJECTIVES
The purpose of this study was to compare the microbial and clinical effects of mechanical debridement (MD) alone or in combination with the application of enamel matrix derivative (EMD) and sustained-release micro-spherical minocycline (MSM) for treatment of peri-implant mucosal infl ammation (PIMI).
MATERIALS AND METHODS
Subjects with at least one implant with PIMI were included and divided into control and two different test groups. In all three groups, MD was performed. In the MSM group, following MD, MSM was placed subgingivally around the implants. In the EMD group, after MD, EMD was placed in the sulcus around the implants. Sampling of peri-implant crevicular fl uid for microbial analysis with real-time polymerase chain reaction and recording of probing depth (PD) and bleeding on probing (BOP) were performed prior to as well as two weeks and three months after treatment. Median values and interquartile range were estimated for each variable during the various assessment intervals of the study.
RESULTS
In all groups, at two weeks and three months, the counts of Porphyromonas gingivalis decreased significantly compared to baseline. Levels of P. gingivalis were significantly reduced in MSM (P<0.001) and EMD (P=0.026) groups compared to the control group. Also, clinical parameters improved significantly at two weeks and three months. Reduction of PD was significant in MSM (P<0.001) and EMD (P<0.001) groups. The decrease in BOP in the MSM, EMD, and control groups was 60%, 50%, and 20%, respectively.
CONCLUSION
The use of MSM and EMD can be an adjunctive treatment for management of PIMI and improves clinical parameters and reduces P. gingivalis burden three months after treatment.

Keyword

Debridement; Infl ammation; Minocycline; Real-time polymerase chain reaction; Peri-implantitis

MeSH Terms

Debridement
Dental Enamel*
Hemorrhage
Inflammation*
Minocycline*
Peri-Implantitis
Porphyromonas gingivalis
Real-Time Polymerase Chain Reaction
Minocycline

Figure

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  Fig. 1 Study flowchart.Masumeh Faramarzi et al: Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. J Korean Assoc Oral Maxillofac Surg 2015

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