J Vet Sci.  2016 Mar;17(1):111-113. 10.4142/jvs.2016.17.1.111.

Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs

• Ponchon T
• Lopez Merlo M
• Faya M
• Priotto M
• Barbeito C
• Gobello C

• KMID: 2363342
• DOI: http://doi.org/10.4142/jvs.2016.17.1.111

Abstract

To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm2 of endometrium nor in the height of the uterine epithelium.

Keyword

canid; contraception; endocrine disruption; genital tract; neonatal

MeSH Terms

Animals
Animals, Newborn
Clitoris/drug effects
Dogs
Epithelium/*drug effects
Female
Medroxyprogesterone Acetate/*pharmacology
Organ Size/drug effects
Random Allocation
Sexual Maturation/drug effects
Uterus/*drug effects
Medroxyprogesterone Acetate

Figure

• 

  Fig. 1 Uterus of female dogs treated postnatally with medroxyprogesterone acetate 10 mg/100 g subcutaneously (s.c) (A) or Placebo s.c. (B) and hysterectomized after pubertal estrous cycle. Notice normal uterine gland pattern in both treatments. *Stroma. †Glandular epithelium. H&E stain. Scale bars = 20 µm.

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