Ann Lab Med.  2015 Nov;35(6):663-665. 10.3343/alm.2015.35.6.663.

Isochromosome 1q in Childhood Burkitt Lymphoma: The First Reported Case in Korea

Affiliations
  • 1Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. CJR0606@yuhs.ac
  • 2Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Bone Marrow/pathology
Burkitt Lymphoma/*diagnosis/genetics
Child
Chromosomes, Human, Pair 1
Female
Flow Cytometry
Humans
Immunoglobulin Heavy Chains/genetics
Isochromosomes/*genetics
Karyotype
Karyotyping
Proto-Oncogene Proteins c-myc/genetics
Republic of Korea
Translocation, Genetic
Immunoglobulin Heavy Chains
Proto-Oncogene Proteins c-myc

Figure

  • Fig. 1 Microscopic morphological examination of the patient's (A) peripheral blood, and (B) bone marrow touch imprint preparation (Wright-Giemsa stain, ×1,000).

  • Fig. 2 (A) The G-banded karyotype of the patient. Trypsin-Giemsa banded chromosome analysis at 550-band level shows a marker chromosome, which is suspected to be isochromosome 1q (red arrow), as well as the translocation involving 8q24 and 14q32 (blue arrow). (B) Interphase FISH by using Vysis locus-specific identifier (LSI) dual color IGH/c-MYC probe set (Abbott Molecular/Vysis, Downers Grove, IL, USA). Two fusion signals of the 8q24 (c-MYC) and 14q32 (IGH) probes with an additional red and green signal for c-MYC and IGH, respectively indicate translocation involving the two genes. (C) Interphase FISH by using Metasystems LSI dual color CDKN2C/CKS1B probe set (Metasystems, Altlussheim, Germany). Two green and four red signals for 1p32 (CDKN2C) and 1q21 (CKS1B), respectively indicate the presence of isochromosome 1q.


Reference

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