Pediatr Infect Vaccine.  2016 Dec;23(3):223-228. 10.14776/piv.2016.23.3.223.

Infection of Extended-Spectrum β-Lactamase Producing Shigella flexneri in Children Attending a Childcare Center in Korea

• Nam EW
• Lee KS
• Kim J
• Yoo CK

• KMID: 2362482
• DOI: http://doi.org/10.14776/piv.2016.23.3.223

Abstract

Shigella is a common cause of bacterial enteritis worldwide. Shigella sonnei accounts for 90% of Shigella infections and Shigella flexneri is rarely reported in Korea. Although the incidence of Shigella infection has decreased, the incidence of organisms with antibiotic resistance has gradually increased in Korea. An outbreak of extended-spectrum β-lactamase (ESBL)-producing S. sonnei in children was reported in Korea; however, ESBL-producing S. flexneri has not yet been reported. We report the first two cases of multidrug-resistant CTX-M-14-producing S. flexneri infections in Korean children.

Keyword

Shigella; Beta-lactamases

MeSH Terms

beta-Lactamases
Child*
Drug Resistance, Microbial
Enteritis
Humans
Incidence
Korea*
Shigella flexneri*
Shigella sonnei
Shigella*
beta-Lactamases

Figure

• 

  Fig. 1 The pulsed filed gel electrophoresis (PFGE)-NotI patterns from outbreak strains of Shigella flexneri 2a. AMP, ampicillin; SAM, amoxicillin/clavulanic acid; CEP, cephalothin; CTX, cefotaxime; NAL, nalidixic acid; CHL, chloramphenicol; TET, tetracycline; SXT, trimethoprim-sulfamethoxazole.

• 

  Fig. 2 Detection of extended-spectrum β-lactamases by multiplex polymerase chain reaction. M, 100 bp ladder; 1, outbreak 1; 2, outbreak 2; and 3, negative control. 501 bp. blactx-m14; 296 bp, blaoxa-1.

• 

  Fig. 3 The clinical course: duration of fever (A) and frequency of diarrhea (B).

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