Ann Dermatol.  1995 Jan;7(1):51-53. 10.5021/ad.1995.7.1.51.

The Effect on Liver Transaminases of 5-Methoxypsoralen Used in Systemic Photochemotherapy

• Choi HJ
• Kim S
• Hann SK
• Park YK

• KMID: 2361413
• DOI: http://doi.org/10.5021/ad.1995.7.1.51

Abstract

BACKGROUND
PUVA therapy has been used to treat psoriasis, vitiligo, and various cutaneous diseases. Psoralens are metabolized in the liver and thus can produce liver damage.
OBJECTIVE
This study was done to observe the effect of 5-methoxypsoralen on liver function during photochemotherapy.
METHODS
Serum transaminase levels were determined before and during photochemotherapy in eighty patients with vitiligo or psoriasis.
RESULTS
Four of the eighty patients who had received 5-MOP-PUVA showed elevation of serum transaminase levels.
CONCLUSION
Although there have been few cases showing transient elevated values of serum transaminase during 5-MOP-PUVA, it is advisable to obtain liver function tests before and serially during photochemotherapy.

Keyword

Hepatotoxicity; 5-Methoxypsoralen; Photochemotherapy

MeSH Terms

Ficusin
Furocoumarins
Humans
Liver Function Tests
Liver*
Photochemotherapy*
Psoriasis
PUVA Therapy
Transaminases*
Vitiligo
Ficusin
Furocoumarins
Transaminases