J Rhinol.  2016 Nov;23(2):110-114. 10.18787/jr.2016.23.2.110.

A Case of Small Cell Carcinoma of the Maxillary Sinus Coexisting with Fungus Ball

• Yeo SC
• Cho HJ
• Kim SW
• Jeon SY

• KMID: 2361324
• DOI: http://doi.org/10.18787/jr.2016.23.2.110

Abstract

Small cell carcinoma commonly originates in the lung, with only about 4% of cases arising at extrapulmonary sites. Furthermore, small cell carcinoma of the sinonasal tract is extremely rare. In Korea, only 2 cases of primary sinonasal small cell carcinoma have been reported in the nasal cavity and the nasal septum, respectively. Recently, we have experienced a rare case of small cell carcinoma arising from the right maxillary sinus coexisting with a fungal ball lesion. Herein, we report this case with a review of the literature.

Keyword

Small cell carcinoma; Paranasal sinus; Maxillary sinus; Aspergillosis

MeSH Terms

Aspergillosis
Carcinoma, Small Cell*
Fungi*
Korea
Lung
Maxillary Sinus*
Nasal Cavity
Nasal Septum

Figure

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  Fig. 1. Endoscopic findings of the Rt. nasal cavity. Well demarcated mass with soft surface ranged from the middle meaus to inferior meatus. IT: Inferior turbinate, S: nasal septum.

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  Fig. 2. Axial (A) and coronal (B) PNS CT scan. Soft tissue density lesion at Rt. maxillary, ethmoid, sphenoid sinus and nasal cavity with bony destruction of anterior and posterior maxillary sinus wall (astrix) and orbit (arrow).

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  Fig. 3. T1 enhance (A) and T2 weighted (B) MR image. Heterogeneous signal intensity mass lesion at Rt. maxillary sinus extent to nasal cavity and invade the orbit (astrix) and buccal fat pad (arrow).

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  Fig. 4. Histopathologic findings. A: Round and spindle shaped cell with small amount of cytoplasm and abundent nucleus showing abundent cell division (H-E stain, ×400). B: Staining for aspergillus fungus ball (H-E stain, ×400).

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  Fig. 5. Immunohistochemical study. A: Positive staining for CD 56 (×200). B: Positive staining for synaptophysin (×200).

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  Fig. 6. Post-operative 6 month follow up axial (A) and coronal (B) CT scan image. The tumor maintained in partial remission state.

Reference

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