Ann Dermatol.  1999 Apr;11(2):101-105. 10.5021/ad.1999.11.2.101.

A Case of Primary Cutaneous CD30(Ki-1)-positive Large Cell Lymphoma Showing Repetitive Spontaneous Regression and Recurrences

Abstract

Primary cutaneous CD30+ large cell lymphoma(LCL) is a rare cutaneous peripheral T cell lymphoma with a favorable prognosis. This lymphoma characteristically presents itself as a solitary or localized skin tumor with frequent cutaneous relapses and partial or complete spontaneous remission. Recently we saw a sixty-three year old male who had developed primary cutaneous CD30+ large cell lymphoma that waxed and waned. He presented with localized multiple nodules that had shown repetitive spontaneous regression and recurrences with the same morphology in the same area for several years. There was no evidence of nodal and visceral involvement. The immunohistochemical studies demonstrated that most neoplastic cells in the tumor were positive for CD30 and pan-T cells and negative for pan-B cells, S-100 proteins, EMA and monocyte-macrophage related antigen(CD68).

Keyword

CD30(Ki-1)+LCL; Spontaneous regression and recurrence

MeSH Terms

Humans
Lymphoma*
Lymphoma, T-Cell, Peripheral
Male
Prognosis
Recurrence*
Remission, Spontaneous
S100 Proteins
Skin
S100 Proteins
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