J Korean Radiol Soc.  1990 Oct;26(5):841-849. 10.3348/jkrs.1990.26.5.841.

An experimental study on renal damage induced by ionic contrast media in relation to iodine concentration

Abstract

Renal injury caused by iodinated contrast media has been widely known, but there has been few papers regardingthe pathological change. A series of rat kidneys after injection of iodinated contrast media was examined todocument pathological change. A total of 80 rats was divided into two groups: those given Urografin-60% by 5ml/kg;those given Urografin-76% by 5ml/kg. The kidneys were removed out 1,2,3,4,7,10,14, and 21 days after injection ofcontrast media and microscopically examined. The results were as follows: 1. Pathological changes induced by ioniccontrast media were deposition of proteinaceous materials in the proximal convoluted tubules, congestion ofinterstitial vessels, and vasa rectae, and epithelial degeneration of collecting ducts. There was no detectablepathological changes in the glomerulus, loop of Henle, and distal convoluted tubules. 2. All the pathologicalchanges were seavere, as the concentration of contrast media increased. 3. These pathologic changes appeared 1 dayafter injection of contrast media and persisted at least 3 weeks without improvement. Author concludes that therenal damage induced by ionic contrast media becomes severe with increase in concentration, and pathologic changesare not influenced with time interval.


MeSH Terms

Animals
Contrast Media*
Estrogens, Conjugated (USP)
Iodine*
Kidney
Loop of Henle
Rats
Contrast Media
Estrogens, Conjugated (USP)
Iodine
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