J Korean Ophthalmol Soc.  2016 Nov;57(11):1786-1789. 10.3341/jkos.2016.57.11.1786.

A Case of Primary Conjunctival Giant Cell Tumor

• Kim TH
• Oh HN

• KMID: 2357737
• DOI: http://doi.org/10.3341/jkos.2016.57.11.1786

Abstract

PURPOSE
To report a case of primary conjunctival giant cell tumor (GCT).
CASE SUMMARY
A 67-year-old female visited our clinic with the chief complaint of a 10-year-history of conjunctival mass in the left eye. The patient had no marked changes in the mass size, and her visual acuity and intraocular pressure were within the normal range. The protruding conjunctival mass invaded the limbal area at the 8 o'clock direction in the left eye and was 5 × 4 × 2 mm in size. Moreover, the pink-colored mass had a lobulated shape with a well-defined margin. In the adjacent mass region, concurrent presence of the conjunctival injection was observed. However, the patient did not exhibit pain or tenderness. We performed wide excision of the conjunctival mass concomitantly with amniotic membrane transplantation. Then, histopathological examinations and immunohistochemical staining of the surgical site were performed. On histopathology, the patient had findings suggestive of GCT. Additionally, immunohistochemistry was positive for CD68 and vimentin. leading to the final diagnosis of GCT.
CONCLUSIONS
To our knowledge, this is the first case of GCT of the conjunctiva, which has not been described in the literature. Our case highlights the importance of differential diagnosis from other protuberant conjunctival tumors. A complete removal of GCT of the conjunctiva and a recovery of aesthetic outcomes can be achieved by surgical excision of the mass.

Keyword

Conjunctival mass; Primary conjunctival giant cell tumor

MeSH Terms

Aged
Amnion
Conjunctiva
Diagnosis
Diagnosis, Differential
Female
Giant Cell Tumors*
Giant Cells*
Humans
Immunohistochemistry
Intraocular Pressure
Reference Values
Vimentin
Visual Acuity
Vimentin

Figure

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  Figure 1. Photograph of the conjunctival mass at medial side of left eye. Well circumscribed, lobulated, protruding pinkish mass.

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  Figure 2. Histological and Immunohistochemical examination of conjunctival giant cell tumor. (A) Multinucleated giant cells (＊) interspersed among mononuclear cells (arrows) (H&E ×200). (B) Positive staining for CD68 (arrow) (×200). (C) Positive staining for Vimentin (arrow) (×200). (D) Negative staining for smooth muscle actin (×200).

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  Figure 3. Conjunctival appearance at 6months after surgical resection. The mass was completely removed and there was no local recurrence.

Reference

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