Korean J Anesthesiol.  1981 Mar;14(1):14-19.

The Effect of Propranolol on the Blood Pressure and Pulse Rate under Halothane Anesthesia

• Ko BS
• Ha IH

Abstract

To combat the cardiovascular depression in blood pressure and palserate induced by halothane anesthesia in healthy persons after administration of propranolol(1.0mg) by the intravenous route, atropnie sulfate(0.5mg), ephedrine Hcl(20mg) and aramine(1.0mg) were administered respectively i.v. The results were as follows: 1) After i.v. administration of atropine sulfate, systolic blood pressure was elevated by 15 mmHg, diastolic blood pressure was elevated by 13mmHg, and pulse rate was increased by 24 per minute. 2) After i.v. administration of ephedrine, systolic blood pressure was elevated by 27 mmHg, diastolic blood pressure was elevated by 17mmHg, but significant pulse rate change was not observed. 3) After i.v. administration of aramine, systolic blood pressure was elevated by 29mmHg, diastolic blood pressure was elevated by 19mmHg, but pulse rate was decreased by 8 per minute. 4) As shown in the above results, in the cardiovascular depression due to halothane anesthesia after propranolol intravenous administration, blood pressure and pulse rated were corrected by treatment with atropine sulfate. Ephedrine and aramine effected elevation of the blood pressure, but not the pulse rate.

MeSH Terms

Administration, Intravenous
Anesthesia*
Atropine
Blood Pressure*
Depression
Ephedrine
Halothane*
Heart Rate*
Humans
Metaraminol
Propranolol*
Atropine
Ephedrine
Halothane
Metaraminol
Propranolol