J Korean Soc Med Inform.  2009 Mar;15(1):59-69.

Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine

• Moon J
• Park K
• Choi S

Abstract

OBJECTIVE
This study aims to develop the web-interface creator, which automatically changes the Case Report Form(CRF) web page when the protocol developer in any clinical study revises the ontology of CRF.
METHODS
This study established the conceptual model of CRF on oriental and western medicine, and developed ontologies. A program was developed to produce online-based a input form through the parser that generates automatically HTML script from OWL.
RESULTS
The CRF applied in this study is a draft through consensus of experts for stroke research at the Korea Institute of Oriental Medicine. The ontology of CRF consisted of Label, ControlType and Value classes and hasControl, hasValue and hasSymptoms properties. The Label is the class of question items groups, so it could have CRF questionnaire instances. The ControlType is the class that expresses controls such as checkbox, text, etc in the HTML script. The Value class represents selections for each items. Finally, the HTML script was created by XSL transformation from the OWL script.
CONCLUSION
Online-based automatic interface creation, which enables immediate coping with the continuous change in the medical knowledge system, assures reduced time requirement.

Keyword

Ontology; OWL; XSLT; Electronic Case Report Form; Clinical Research

MeSH Terms

Consensus
Korea
Medicine, East Asian Traditional*
Strigiformes
Stroke

Figure

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  Figure 1 Sequence diagram of e-CRF

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  Figure 2 Process of programming

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  Figure 3 Conceptual framework for patient findings-ISO/TC 215 DTS 22789

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  Figure 4 Conceptual model of OntoCRF in cerebrovascular disease

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  Figure 5 Classes(left) and properties(right)

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  Figure 6 ControlType instance

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  Figure 7 Instance Tab

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  Figure 8 hasValue property

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  Figure 9 hasUnit property

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  Figure 10 Structured view of OntoCRF by OntoViz

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  Figure 11 Relationship View using TGVizTab

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  Figure 12 Queries tab to search instances

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  Figure 13 XSL algorithms for transformation from OWL to HTML

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  Figure 14 Output to HTML

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